Title:
C-MYC PROTEIN INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/004391
Kind Code:
A1
Abstract:
Provided are a c-Myc protein inhibitor, and a preparation method therefor and use thereof. The c-Myc protein inhibitor selectively inhibits c-Myc protein. Therefore, the inhibitor can be used for prevention and treatment of diseases related to c-Myc protein disorders, such as cancers, cardiovascular and cerebrovascular diseases, diseases related to virus infection.
Inventors:
TONG YOUZHI (US)
LAI LUHUA (CN)
LAI LUHUA (CN)
Application Number:
PCT/CN2020/100103
Publication Date:
January 14, 2021
Filing Date:
July 03, 2020
Export Citation:
Assignee:
SUZHOU KINTOR PHARMACEUTICALS INC (CN)
International Classes:
C07F5/02; A61K31/69; A61P31/12; A61P31/14; A61P31/16; A61P31/18; A61P31/20; A61P31/22; A61P35/00; A61P35/02
Foreign References:
| US20090099132A1 | 2009-04-16 | |||
| US20140296307A1 | 2014-10-02 | |||
| CN107522700A | 2017-12-29 |
Other References:
YONGQIANG ZHU ET AL.: "Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship (SAR) Discussion of Dipeptidyl Boronate Proteasome Inhibitors, Part I:Comprehensive Understanding of the SAR of r-Amino Acid Boronates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 14, 18 June 2009 (2009-06-18), XP002638799, DOI: 20200917093616X
MENG LEI ET AL.: "3D-QSAR-aided Design, Synthesis, In Vitro and In Vivo Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors and Mechanism Studies", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, 13 April 2016 (2016-04-13), XP029527578, DOI: 20200917094304X
STANLEY C.XIE ET AL.: "Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, 29 October 2018 (2018-10-29), XP055772397, DOI: 20200917094851X
JOANNE TAN ET AL.: "De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX", JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, 12 June 2019 (2019-06-12), XP055772401, DOI: 20200917095947X
MENG LEI ET AL.: "3D-QSAR-aided Design, Synthesis, In Vitro and In Vivo Evaluation of Dipeptidyl Boronic Acid Proteasome Inhibitors and Mechanism Studies", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, 13 April 2016 (2016-04-13), XP029527578, DOI: 20200917094304X
STANLEY C.XIE ET AL.: "Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome", JOURNAL OF MEDICINAL CHEMISTRY, vol. 61, 29 October 2018 (2018-10-29), XP055772397, DOI: 20200917094851X
JOANNE TAN ET AL.: "De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX", JOURNAL OF MEDICINAL CHEMISTRY, vol. 62, 12 June 2019 (2019-06-12), XP055772401, DOI: 20200917095947X
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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