CADHERIN-LIKE ASYMMETRY PROTEIN-1, AND METHODS FOR ITS USE

Title:

CADHERIN-LIKE ASYMMETRY PROTEIN-1, AND METHODS FOR ITS USE

Document Type and Number:

WIPO Patent Application WO2000020434

Kind Code:

A9

Abstract:

The present invention relates to molecules involved in cell-cell interactions in the immune system. In particular, the invention relates to a cell surface protein which contains certain classical cadherin characteristics, but it exhibits an apical distribution pattern on the surface of lymphocytes. The membrane location of this molecule correlates with the contact interface between T and B cells, and antibodies against an extracellular domain of this protein disrupt T cell/B cell interactions.

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Inventors:

LU PETER S
DAVIS MARK M

Application Number:

PCT/US1999/022996

Publication Date:

August 24, 2000

Filing Date:

October 01, 1999

Export Citation:

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Assignee:

UNIV LELAND STANFORD JUNIOR (US)

International Classes:

C12N15/09; A61K31/711; A61K35/76; A61K38/00; A61K39/395; A61K48/00; A61P3/10; A61P17/00; A61P19/02; A61P25/00; A61P29/00; A61P37/02; C07K14/705; C07K16/28; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12P21/08; C12Q1/02; (IPC1-7): C07H21/04; A61K39/395; C07K14/705; C12N15/09; C12Q1/68; C12N16/63

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