Title:
THE CAGE GENE OF ACTINOBACILLUS ACTINOMYCETEMCOMITANS, THE PROTEIN IT ENCODES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003002745
Kind Code:
A3
Abstract:
A gene and protein isolated from A. actinomycetemcomitans is described. The protein, designated CagE, can induce apoptosis and cell adhesion. The invention includes all diagnostic and therapeutic uses of the protein and antibodies to the protein.
Inventors:
TENG YEN-TUNG A (CA)
Application Number:
PCT/CA2002/000963
Publication Date:
December 11, 2003
Filing Date:
June 27, 2002
Export Citation:
Assignee:
UNIV WESTERN ONTARIO (CA)
TENG YEN-TUNG A (CA)
TENG YEN-TUNG A (CA)
International Classes:
C07K14/36; C12N15/31; A61K38/00; A61K39/00; A61K48/00; (IPC1-7): C12N15/31; C07K14/36; C07K16/12; G01N33/569; C12Q1/68; A61K39/02; A61K48/00; A61K39/40; G01N33/68; C12Q1/02
Other References:
CENSINI STEFANO ET AL: "Cag, A pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 93, no. 25, 1996, 1996, pages 14648 - 14653, XP002246958, ISSN: 0027-8424
FIVES-TAYLOR, P ET AL.: "Virulence factors of Actinobacillus actinomycetemcomitans.", PERIDONTOLOGY 2000, vol. 20, 1999, pages 136 - 167, XP008018858
FIVES-TAYLOR P ET AL: "VIRULENCE FACTORS OF THE PERIODONTOPATHOGEN ACTINOBACILLUS ACTINOMYCETEMCOMITANS", JOURNAL OF PERIODONTOLOGY, AMERICAN ACADEMY OF PERIODONTOLOGY, CHICAGO, IL, US, vol. 67, no. 3, SUPPL, 1996, pages 291 - 297, XP008018836, ISSN: 0022-3492
TENG Y-T A ET AL: "PERIODONTAL IMMUNE RESPONSES OF HUMAN LYMPHOCYTES IN ACTINOBACILLUS ACTINOMYCETEMCOMITANS-INOCULATED NOD/SCID MICE ENGRAFTED WITH PERIPHERAL BLOOD LEUKOCYTES OF PERIDONTITIS PATIENTS", JOURNAL OF PERIODONTAL RESEARCH, COPENHAGEN, DK, vol. 34, no. 1, 1999, pages 54 - 61, XP008018859
XING G ET AL: "MUTATION ANALYSIS OF A BACTERIAL TYPE-IV SECRETION PROTEIN CAGE HOMOLOGUE, IN ACTINOBACILLUS ACTINOMYCETEMCOMITANS THAT INDUCES APOPTOSIS OF HUMAN EPITHELIAL CELLS", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, THE SOCIETY, WASHINGTON, DC, US, vol. 102, 19 May 2002 (2002-05-19), pages 81, XP008018835, ISSN: 1060-2011
FIVES-TAYLOR, P ET AL.: "Virulence factors of Actinobacillus actinomycetemcomitans.", PERIDONTOLOGY 2000, vol. 20, 1999, pages 136 - 167, XP008018858
FIVES-TAYLOR P ET AL: "VIRULENCE FACTORS OF THE PERIODONTOPATHOGEN ACTINOBACILLUS ACTINOMYCETEMCOMITANS", JOURNAL OF PERIODONTOLOGY, AMERICAN ACADEMY OF PERIODONTOLOGY, CHICAGO, IL, US, vol. 67, no. 3, SUPPL, 1996, pages 291 - 297, XP008018836, ISSN: 0022-3492
TENG Y-T A ET AL: "PERIODONTAL IMMUNE RESPONSES OF HUMAN LYMPHOCYTES IN ACTINOBACILLUS ACTINOMYCETEMCOMITANS-INOCULATED NOD/SCID MICE ENGRAFTED WITH PERIPHERAL BLOOD LEUKOCYTES OF PERIDONTITIS PATIENTS", JOURNAL OF PERIODONTAL RESEARCH, COPENHAGEN, DK, vol. 34, no. 1, 1999, pages 54 - 61, XP008018859
XING G ET AL: "MUTATION ANALYSIS OF A BACTERIAL TYPE-IV SECRETION PROTEIN CAGE HOMOLOGUE, IN ACTINOBACILLUS ACTINOMYCETEMCOMITANS THAT INDUCES APOPTOSIS OF HUMAN EPITHELIAL CELLS", ABSTRACTS OF THE GENERAL MEETING OF THE AMERICAN SOCIETY FOR MICROBIOLOGY, THE SOCIETY, WASHINGTON, DC, US, vol. 102, 19 May 2002 (2002-05-19), pages 81, XP008018835, ISSN: 1060-2011
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