Title:
CALCIUM CHANNEL INHIBITORS COMPRISING BENZHYDRIL SPACED FROM PIPERAZINE
Document Type and Number:
WIPO Patent Application WO2004089922
Kind Code:
A3
Abstract:
Certain piperazine substituted compounds are described which are useful in altering calcium channel activity.
Inventors:
BELARDETTI FRANCESCO (CA)
PAJOUHESH HASSAN (CA)
PAJOUHESH HOSSEIN (CA)
SNUTCH TERRANCE P (CA)
ZAMPONI GERALD W (CA)
PAJOUHESH HASSAN (CA)
PAJOUHESH HOSSEIN (CA)
SNUTCH TERRANCE P (CA)
ZAMPONI GERALD W (CA)
Application Number:
PCT/CA2004/000539
Publication Date:
March 24, 2005
Filing Date:
April 08, 2004
Export Citation:
Assignee:
NEUROMED TECH INC (CA)
BELARDETTI FRANCESCO (CA)
PAJOUHESH HASSAN (CA)
PAJOUHESH HOSSEIN (CA)
SNUTCH TERRANCE P (CA)
ZAMPONI GERALD W (CA)
BELARDETTI FRANCESCO (CA)
PAJOUHESH HASSAN (CA)
PAJOUHESH HOSSEIN (CA)
SNUTCH TERRANCE P (CA)
ZAMPONI GERALD W (CA)
International Classes:
A61K31/4468; A61K31/451; A61K31/4515; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/498; A61K31/506; A61K31/5375; A61K31/538; A61K31/5415; C07D211/14; C07D211/16; C07D211/46; C07D211/58; C07D213/38; C07D277/74; C07D277/82; C07D295/03; C07D295/185; C07D317/60; C07D401/04; C07D401/14; C07D295/02; (IPC1-7): C07D295/08; A61K31/495
Domestic Patent References:
| WO2001045709A1 | 2001-06-28 | |||
| WO2003068759A1 | 2003-08-21 | |||
| WO2001049670A1 | 2001-07-12 |
Foreign References:
| US20010029258A1 | 2001-10-11 | |||
| US20040034035A1 | 2004-02-19 | |||
| US6387897B1 | 2002-05-14 | |||
| US6294533B1 | 2001-09-25 | |||
| US5646149A | 1997-07-08 | |||
| GB920416A | 1963-03-06 |
Other References:
WEBSTER, KERRI L. ET AL: "Design and preparation of serine-threonine protein phosphatase inhibitors based upon the nodularin and microcystin toxin structures. Part 3", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1 , (14), 1673-1695 CODEN: JCSPCE; ISSN: 1472-7781, 2001, XP002304005
JAMIESON, CRAIG ET AL: "A rapid approach for the optimization of polymer supported reagents in synthesis", SYNLETT , (11), 1603-1607 CODEN: SYNLES; ISSN: 0936-5214, 2000, XP001056501
BOGER, DALE L. ET AL: "Non-amide-based combinatorial libraries derived from N-BOC-iminodiacetic acid: solution-phase synthesis of piperazinone libraries with activity against LEF-1/.beta.-catenin-mediated transcription", HELVETICA CHIMICA ACTA , 83(8), 1825-1845 CODEN: HCACAV; ISSN: 0018-019X, 2000, XP002304006
TOLDY L ET AL: "VERSUCHE ZUR HERSTELLUNG VON PHENTIAZINEN SELEKTIVER CORONARDILATATORISCHER WIRKUNG", ACTA CHIMICA ACADEMIAE SCIENTIARUM HUNGARICA, BUDAPEST, HU, vol. 44, 1965, pages 301 - 325, XP000996141, ISSN: 0001-5407
JAMIESON, CRAIG ET AL: "A rapid approach for the optimization of polymer supported reagents in synthesis", SYNLETT , (11), 1603-1607 CODEN: SYNLES; ISSN: 0936-5214, 2000, XP001056501
BOGER, DALE L. ET AL: "Non-amide-based combinatorial libraries derived from N-BOC-iminodiacetic acid: solution-phase synthesis of piperazinone libraries with activity against LEF-1/.beta.-catenin-mediated transcription", HELVETICA CHIMICA ACTA , 83(8), 1825-1845 CODEN: HCACAV; ISSN: 0018-019X, 2000, XP002304006
TOLDY L ET AL: "VERSUCHE ZUR HERSTELLUNG VON PHENTIAZINEN SELEKTIVER CORONARDILATATORISCHER WIRKUNG", ACTA CHIMICA ACADEMIAE SCIENTIARUM HUNGARICA, BUDAPEST, HU, vol. 44, 1965, pages 301 - 325, XP000996141, ISSN: 0001-5407
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