CALIXARENES AS INHIBITORS OF PROTEIN KINASE B

Title:

CALIXARENES AS INHIBITORS OF PROTEIN KINASE B

Document Type and Number:

WIPO Patent Application WO2005023744

Kind Code:

A3

Abstract:

The present invention provides compounds useful in inhibiting protein kinase B (PKB/Akt). Compositions comprising such compounds and their use are also provided.

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Inventors:

WOSCHOLSKI RUDIGER (DE)
HAILES HELEN CLAIRE (GB)
NUMBERE MACBA GOLDA (GB)

Application Number:

PCT/GB2004/003858

Publication Date:

April 28, 2005

Filing Date:

September 09, 2004

Export Citation:

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Assignee:

IMP COLLEGE INNOVATIONS LTD (GB)
WOSCHOLSKI RUDIGER (DE)
HAILES HELEN CLAIRE (GB)
NUMBERE MACBA GOLDA (GB)

International Classes:

C07C43/225; C07C217/60; (IPC1-7): C07C217/60; A61K31/137; A61P35/00

Foreign References:

US5489612A

1996-02-06

Other References:

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DATABASE BEILSTEIN XP002316668, retrieved from XFIRE Database accession no. 2202136, 2201059
DATABASE BEILSTEIN XP002316669, retrieved from XFIRE Database accession no. 2033914, 2321545, 2321531, 2321501, 2321425
DATABASE BEILSTEIN XP002316670, retrieved from XFIRE Database accession no. 7107983
DATABASE BEILSTEIN XP002316671, retrieved from XFIRE Database accession no. 8246205
DATABASE BEILSTEIN XP002316672, retrieved from XFIRE Database accession no. 4345531, 6262891, 6264375, 6266322
DATABASE BEILSTEIN XP002316673, retrieved from XFIRE Database accession no. 7900556
DATABASE BEILSTEIN XP002316674, retrieved from XFIRE Database accession no. 9111720
DATABASE BEILSTEIN XP002316675, retrieved from XFIRE Database accession no. 9542841
DATABASE BEILSTEIN XP002316676, retrieved from XFIRE Database accession no. 4366883
YOUHENG SHI AND HANS-JÖRG SCHNEIDER: "Interactions between aminocalixarenes and nucleotides or nucleic acids", J. CHEM. SOC. PERKIN TRANS. 2, vol. 8, 1999, pages 1797 - 1803, XP002316666
DATABASE BEILSTEIN XP002316677, retrieved from XFIRE Database accession no. 6080255

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