Title:
CALPAIN INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2023/249007
Kind Code:
A1
Abstract:
The present invention provides a calpain inhibitor that has excellent calpain inhibitive capacity. The present invention provides a compound represented by general formula (I), or a salt thereof. (In formula (I), R1 represents a hydrogen atom, an alkyl group that may be substituted, or the like, or may be bonded with R2 to form a ring; R2 and R3 each independently represent a hydrogen atom or the like, or R2 and R3 may be bonded to form a ring, provided that when R2 and R1 are bonded to form a ring including a double bond, R3 may not exist; R4 represents a hydrogen atom, an alkyl group that may be substituted, or the like; R5 represents a hydrogen atom, an alkyl group that may be substituted, or the like; R6 represents a halogen, a cycloalkyl group that may be substituted, or the like; X represents O or S; when R1 and R2 are bonded to form a ring, R1 may represent O, S, or N, and R2 may represent O or S; and L represents an amide bond.)
Inventors:
SUZUKI YUKI (JP)
SANO YUSUKE (JP)
SANO YUSUKE (JP)
Application Number:
PCT/JP2023/022740
Publication Date:
December 28, 2023
Filing Date:
June 20, 2023
Export Citation:
Assignee:
GORYO CHEMICAL INC (JP)
International Classes:
C07C237/06; A61K31/16; A61K31/165; A61K31/341; A61K31/42; A61K31/421; A61P3/10; A61P9/00; A61P11/00; A61P21/00; A61P25/00; A61P27/02; A61P27/06; A61P27/12; A61P29/00; A61P31/00; A61P35/00; A61P37/06; A61P43/00; C07D261/18; C07D263/34; C07D307/68
Domestic Patent References:
| WO2012021788A2 | 2012-02-16 | |||
| WO2012021800A2 | 2012-02-16 | |||
| WO2004009537A1 | 2004-01-29 | |||
| WO2022129953A1 | 2022-06-23 |
Foreign References:
| US5514694A | 1996-05-07 | |||
| US20110166141A1 | 2011-07-07 | |||
| JP2021534133A | 2021-12-09 |
Other References:
LI ZHAOZHAO,ET AL: "Novel Peptidyl .alpha.-Keto Amide Inhibitors of Calpains and Other Cysteine Proteases", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 39, no. 20, 1 January 1996 (1996-01-01), US , pages 4089 - 4098, XP002323651, ISSN: 0022-2623, DOI: 10.1021/jm950541c
Attorney, Agent or Firm:
MOMII Takafumi (JP)
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