Title:
CALSEQUESTRIN-BASED METAL ION REACTIVE PARTICLE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/158286
Kind Code:
A1
Abstract:
The present invention pertains to a calsequestrin-based metal ion reactive particle and uses thereof. More specifically, the present invention pertains to: a calsequestrin-based metal ion reactive particle prepared by binding a physiologically active substance widely used in medicines and cosmetics to calsequestrin (CSQ) and then reacting same with metal ions; and uses thereof in drug delivery systems, pharmaceutical compositions, or vaccines. The metal ion reactive particle according to the present invention can increase the in vivo and in vitro stability, activity retention time, in vivo half-life, and antigen delivery efficiency of the physiologically active substance.
Inventors:
PARK SE HO (KR)
KIM SUNG HYUN (KR)
KIM SUNG HYUN (KR)
Application Number:
PCT/KR2023/002458
Publication Date:
August 24, 2023
Filing Date:
February 21, 2023
Export Citation:
Assignee:
TOOLBIO CO LTD (KR)
International Classes:
A61K9/16; A61K47/64; A61K47/69; A61P3/10; A61P17/02; A61P27/02; A61P29/00; A61P31/00
Foreign References:
| KR20210121585A | 2021-10-08 | |||
| KR20030038541A | 2003-05-16 | |||
| KR20170069452A | 2017-06-21 | |||
| KR20090040979A | 2009-04-28 |
Other References:
V. N. PODUST, SIM B.-C., KOTHARI D., HENTHORN L., GU C., WANG C.-W., MCLAUGHLIN B., SCHELLENBERGER V.: "Extension of in vivo half-life of biologically active peptides via chemical conjugation to XTEN protein polymer", PROTEIN ENGINEERING DESIGN AND SELECTION, IRL PRESS, vol. 26, no. 11, 1 November 2013 (2013-11-01), pages 743 - 753, XP055190651, ISSN: 17410126, DOI: 10.1093/protein/gzt048
Attorney, Agent or Firm:
WETHEPEOPLE IP & LAW FIRM (KR)
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