Title:
CAMEL-DERIVED HIGH-AFFINITY NANOANTIBODY AGAINST SARS-COV-2 α, γ, δ AND ο MUTANTS
Document Type and Number:
WIPO Patent Application WO/2023/216623
Kind Code:
A1
Abstract:
The present invention relates to a camel-derived high-affinity nanoantibody against SARS-CoV-2 α, γ, δ and ο mutants, specifically relates to an antibody specifically binding to an S protein of a novel coronavirus (SARS-CoV-2) and an antigen-binding fragment thereof, and more specifically relates to an antibody or antigen-binding fragment thereof capable of binding with high affinity to S proteins on the surfaces of coronaviruses such as SARS-CoV-2 Alpha(B.1.1.7), Gamma(P.1), Delta(B.1.617.2) and Omicron(B.1.1.529) mutants. The amino acid sequence of the antibody or antigen-binding fragment thereof comprises a CDR1 represented by any one of SEQ ID NOs: 9-15, a CDR2 represented by any one of SEQ ID NOs: 16-21, and a CDR3 represented by any one of SEQ ID NOs: 22-29, and can be used for preventing, detecting, diagnosing or treating infections caused by coronavirus, especially SARS-CoV-2 viruses.
Inventors:
YANG PENGYUAN (CN)
WANG KAI (CN)
LIU LANLAN (CN)
ZHANG XINZHENG (CN)
CAO DUANFANG (CN)
FAN XIAOYI (CN)
WANG KAI (CN)
LIU LANLAN (CN)
ZHANG XINZHENG (CN)
CAO DUANFANG (CN)
FAN XIAOYI (CN)
Application Number:
PCT/CN2022/143348
Publication Date:
November 16, 2023
Filing Date:
December 29, 2022
Export Citation:
Assignee:
INST BIOPHYSICS CAS (CN)
International Classes:
C07K16/10; A61K39/42; A61P31/14; C07K14/165; C07K19/00; C12N15/13; C12N15/62; C12N15/63; G01N33/569
Foreign References:
| CN114805563A | 2022-07-29 | |||
| CN114409768A | 2022-04-29 | |||
| CN112961238A | 2021-06-15 | |||
| CN114456261A | 2022-05-10 | |||
| CN112898437A | 2021-06-04 |
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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