Title:
CAMPTOTHECIN COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/216956
Kind Code:
A1
Abstract:
The present invention relates to a camptothecin compound with anti-tumor activity, a preparation method therefor and use thereof. In particular, the present invention relates to a compound of the following formula or a pharmaceutically acceptable form thereof, a pharmaceutical composition thereof, a preparation method therefor and use thereof. The compound can be used as a medicine for treating diseases in abnormal cell proliferation, (I).
Inventors:
TIAN QIANG (CN)
ZHANG YITAO (CN)
YE JIAN (CN)
LI YILE (CN)
SONG HONGMEI (CN)
GE JUNYOU (CN)
ZHANG YITAO (CN)
YE JIAN (CN)
LI YILE (CN)
SONG HONGMEI (CN)
GE JUNYOU (CN)
Application Number:
PCT/CN2023/092019
Publication Date:
November 16, 2023
Filing Date:
May 04, 2023
Export Citation:
Assignee:
SICHUAN KELUN BIOTECH BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D491/22; A61K31/437; A61P35/00; C07D491/147
Domestic Patent References:
WO2022198232A1 | 2022-09-22 | |||
WO2023020605A1 | 2023-02-23 | |||
WO2023030364A1 | 2023-03-09 | |||
WO2022170971A1 | 2022-08-18 | |||
WO1996038146A1 | 1996-12-05 | |||
WO2022246576A1 | 2022-12-01 | |||
WO2022068878A1 | 2022-04-07 |
Other References:
WEI LI, KAREN H. VEALE, QIFENG QIU, KERSTIN W. SINKEVICIUS, ERIN K. MALONEY, JULIET A. COSTOPLUS, JANET LAU, HELEN L. EVANS, YULIU: "Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 10, 10 October 2019 (2019-10-10), US , pages 1386 - 1392, XP055758576, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.9b00301
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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