Title:
CAMPTOTHECIN DERIVATIVE AND LIGAND-DRUG CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2023/217227
Kind Code:
A1
Abstract:
The present disclosure relates to a ligand-drug conjugate of a novel structure or a pharmaceutically acceptable salt thereof. Specifically, the present disclosure provides a ligand-drug conjugate having a structural general formula represented by Pc-(L-D)n or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising the conjugate, and use thereof in treating a tumor.
Inventors:
FU YAYUAN (CN)
LI ZHEN (CN)
CHEN CHANGYAN (CN)
CHAI XIAOJUAN (CN)
YU ZHIYONG (CN)
TANG FENG (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
LI ZHEN (CN)
CHEN CHANGYAN (CN)
CHAI XIAOJUAN (CN)
YU ZHIYONG (CN)
TANG FENG (CN)
CAO ZHUOXIAO (CN)
TANG RENHONG (CN)
Application Number:
PCT/CN2023/093503
Publication Date:
November 16, 2023
Filing Date:
May 11, 2023
Export Citation:
Assignee:
SIMCERE ZAIMING PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K47/68; A61P35/00; C07D491/22; C07K16/28
Domestic Patent References:
| WO2021067820A1 | 2021-04-08 | |||
| WO2021067861A1 | 2021-04-08 |
Foreign References:
| CN112512592A | 2021-03-16 | |||
| US20210101982A1 | 2021-04-08 |
Other References:
WEI LI, KAREN H. VEALE, QIFENG QIU, KERSTIN W. SINKEVICIUS, ERIN K. MALONEY, JULIET A. COSTOPLUS, JANET LAU, HELEN L. EVANS, YULIU: "Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates", ACS MEDICINAL CHEMISTRY LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 10, no. 10, 10 October 2019 (2019-10-10), US , pages 1386 - 1392, XP055758576, ISSN: 1948-5875, DOI: 10.1021/acsmedchemlett.9b00301
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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