Title:
CANCER CELL DEATH INDUCER HAVING ACTIVITY OF POTENTIATING ANTI-CANCER AGENT IN CANCER HAVING RESISTANCE AGAINST THE ANTI-CANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2009/060982
Kind Code:
A1
Abstract:
Disclosed is a substance capable of recovering the sensitivity of a cancer cell
to an anti-cancer agent and inducing the cell death of the cancer cell in cancer
acquiring the resistance to the anti-cancer agent. Specifically disclosed
is a cancer cell death inducer for a cancer cell having the resistance against
an anti-cancer agent, which comprises DNA for REIC/Dkk-3 as an active ingredient,
and which has an activity of potentiating the anti-cancer agent.
Inventors:
KUMON HIROMI (JP)
NASU YASUTOMO (JP)
WATANABE MASAMI (JP)
KASHIWAKURA YUJI (JP)
KAWASAKI KENSUKE (JP)
NASU YASUTOMO (JP)
WATANABE MASAMI (JP)
KASHIWAKURA YUJI (JP)
KAWASAKI KENSUKE (JP)
Application Number:
PCT/JP2008/070541
Publication Date:
May 14, 2009
Filing Date:
November 05, 2008
Export Citation:
Assignee:
MOMOTARO GENE INC (JP)
KUMON HIROMI (JP)
NASU YASUTOMO (JP)
WATANABE MASAMI (JP)
KASHIWAKURA YUJI (JP)
KAWASAKI KENSUKE (JP)
KUMON HIROMI (JP)
NASU YASUTOMO (JP)
WATANABE MASAMI (JP)
KASHIWAKURA YUJI (JP)
KAWASAKI KENSUKE (JP)
International Classes:
A61K48/00; A61K31/713; A61K35/76; A61K35/761; A61P35/00; A61P35/02; C12N15/09
Domestic Patent References:
| WO2006098074A1 | 2006-09-21 | |||
| WO2006062723A2 | 2006-06-15 | |||
| WO2006016062A1 | 2006-02-16 | |||
| WO2008050898A1 | 2008-05-02 | |||
| WO2001038523A1 | 2001-05-31 |
Other References:
ABARZUA F.: "REIC/Dkk-3 Idenshi ni yoru Hito Zenritsusengan ni Taisuru Idenshi Chiryo no Kiso Jikken", JOURNAL OF MEDICAL ASSOCIATION OF OKAYAMA UNIVERSITY MEDICAL SCHOOL, vol. 119, May 2007 (2007-05-01), pages 21 - 26, XP008134310
EDAMURA K. ET AL.: "Adenovirus-mediated RIEC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model", CANCER GENE THERAPY, vol. 14, June 2007 (2007-06-01), pages 765 - 772, XP008133671
TANIMOTO R. ET AL.: "REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer", INTERNATIONAL JOURANAL OF MOLECULAR MEDICINE, vol. 19, March 2007 (2007-03-01), pages 363 - 368, XP008133672
HARUKI KAKU ET AL.: "Okayama Daigaku ni Okeru Zenritsusengan Idenshi Chiryo Kenkyu no Genkyo to Tenbo", NISHINICHIHITSUNYO, vol. 69, April 2007 (2007-04-01), pages 221 - 229, XP008134314
ABARZUA F.: "An N-termianl 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 375, August 2008 (2008-08-01), pages 614 - 618, XP025428462
See also references of EP 2213309A4
MASUDA Y. ET AL., CANCER CHEMOTHER PHARMACOL., vol. 42, no. 1, 1998, pages 9 - 16
WANG FS ET AL., HUM GENE THER., vol. 10, no. 7, 1 May 1999 (1999-05-01), pages 1185 - 95
YAGUE E. ET AL., GENE THER., vol. 11, no. 14, July 2004 (2004-07-01), pages 1170 - 4
PAMPHLET; TSUJI, T. ET AL., BIOCHEMBIOPHYS RES COMMUN, vol. 268, 2000, pages 20 - 4
TSUJI, T. ET AL., BIOCHEMBIOPHYS RES COMMUN, vol. 289, 2001, pages 257 - 63
NOZAKI, I. ET AL., INT J ONCOL, vol. 19, 2001, pages 117 - 21
KUROSE, K. ET AL., J UROL, vol. 171, 2004, pages 1314 - 8
BAFICO, A. ET AL., NAT CELL BIOL, vol. 3, 2001, pages 683 - 6
HOANG, B.H. ET AL., CANCER RES, vol. 64, 2004, pages 2734 - 9
MOON, R.T. ET AL., SCIENCE, vol. 296, 2002, pages 1644 - 6
MASUDA Y. ET AL., CANCER CHEMOTHER PHARMACOL., vol. 42, no. 1, 1998, pages 9 - 16
WANG FS. ET AL., HUM GENE THER., vol. 10, no. 7, 1 May 1999 (1999-05-01), pages 1185 - 95
TSUJI, T. ET AL., BIOCHEMBIOPHYS RES COMMUN, vol. 268, 2000, pages 20 - 4
"Experimental Medicine, Separate Volume", BASIC TECHNOLOGY FOR GENE THERAPY, 1996
"Experimental Medicine, Separate Volume", GENE TRANSFER & EXPERIMENTAL METHODS FOR EXPRESSION ANALYSIS, 1997
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 1320
LIEBER, A. ET AL., J. VIROL., vol. 70, 1996, pages 8944
MIZUGUCHI, H.; KAY, M. A., HUM. GENE THER., vol. 10, 1999, pages 2013
STEINWAERDER, D. S. ET AL., J. VIROL., vol. 73, 1999, pages 9303
RECCHIA, A. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 96, 1999, pages 2615
MIZUGUCHI, H.; HAYAKAWA, T., NIPPON RINSHO, vol. 7, 2000, pages 1544
GENE, vol. 108, 1991, pages 193 - 200
"NIKKEI SCIENCE", NIKKEI SCIENCE, vol. 36, no. 1, April 1994 (1994-04-01), pages 20 - 45
THE PHARMACEUTICALS MONTHLY, vol. 36, no. 1, 1994, pages 23 - 48
BAI L ET AL., INT J CANCER, vol. 53, 1993, pages 451 - 456
ABARZUA F ET AL., CANCER RES, vol. 65, 2005, pages 9617 - 9622
BELLOC F ET AL., CYTOMETRY, vol. 17, 1994, pages 59 - 65
MACIOROWSKI Z ET AL., CYTOMETRY, vol. 32, 1998, pages 44 - 50
BARZUA F ET AL., CANCER RES, vol. 65, 2005, pages 9617 - 9622
KUROSE K ET AL., ONCOGENE, vol. 171, 2004, pages 1314 - 13181
HSIEH SY, ONCOGENE, vol. 23, 2004, pages 9183 - 9189
BENNETT BL ET AL., PROC NATL ACAD SCI U.S.A., vol. 98, 2001, pages 13681 - 13686
ABARZUA F ET AL., INT J MOL MED, vol. 20, 2007, pages 37 - 43
TANIMOTO R ET AL., INT J MOL MED, vol. 19, 2007, pages 363 - 368
CUDNA RE, BIOTECHNOL BIOENG, vol. 81, 2003, pages 56 - 65
HERR I. ET AL., BLOOD, vol. 98, 2001, pages 2603 - 2614
UEDA K. ET AL., PROC NATL ACAD SCI U.S.A., vol. 84, 1987, pages 3004 - 3008
GIAI M. ET AL., EUR J GYNAECOL ONCOL, vol. 12, 1991, pages 35911 - 373
FUJITA T ET AL., INT J CANCER, vol. 117, 2005, pages 670 - 682
MIAO ZH ET AL., CANCER RES, vol. 63, 2003, pages 4527 - 4532
KIMIYA K. ET AL., J UROL., vol. 148, August 1992 (1992-08-01), pages 441 - 5
HASEGAWA S. ET AL., BR J CANCER., vol. 71, no. 5, May 1995 (1995-05-01), pages 907 - 13
EDAMURA K. ET AL.: "Adenovirus-mediated RIEC/Dkk-3 gene transfer inhibits tumor growth and metastasis in an orthotopic prostate cancer model", CANCER GENE THERAPY, vol. 14, June 2007 (2007-06-01), pages 765 - 772, XP008133671
TANIMOTO R. ET AL.: "REIC/Dkk-3 as a potential gene therapeutic agent against human testicular cancer", INTERNATIONAL JOURANAL OF MOLECULAR MEDICINE, vol. 19, March 2007 (2007-03-01), pages 363 - 368, XP008133672
HARUKI KAKU ET AL.: "Okayama Daigaku ni Okeru Zenritsusengan Idenshi Chiryo Kenkyu no Genkyo to Tenbo", NISHINICHIHITSUNYO, vol. 69, April 2007 (2007-04-01), pages 221 - 229, XP008134314
ABARZUA F.: "An N-termianl 78 amino acid truncation of REIC/Dkk-3 effectively induces apoptosis", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 375, August 2008 (2008-08-01), pages 614 - 618, XP025428462
See also references of EP 2213309A4
MASUDA Y. ET AL., CANCER CHEMOTHER PHARMACOL., vol. 42, no. 1, 1998, pages 9 - 16
WANG FS ET AL., HUM GENE THER., vol. 10, no. 7, 1 May 1999 (1999-05-01), pages 1185 - 95
YAGUE E. ET AL., GENE THER., vol. 11, no. 14, July 2004 (2004-07-01), pages 1170 - 4
PAMPHLET; TSUJI, T. ET AL., BIOCHEMBIOPHYS RES COMMUN, vol. 268, 2000, pages 20 - 4
TSUJI, T. ET AL., BIOCHEMBIOPHYS RES COMMUN, vol. 289, 2001, pages 257 - 63
NOZAKI, I. ET AL., INT J ONCOL, vol. 19, 2001, pages 117 - 21
KUROSE, K. ET AL., J UROL, vol. 171, 2004, pages 1314 - 8
BAFICO, A. ET AL., NAT CELL BIOL, vol. 3, 2001, pages 683 - 6
HOANG, B.H. ET AL., CANCER RES, vol. 64, 2004, pages 2734 - 9
MOON, R.T. ET AL., SCIENCE, vol. 296, 2002, pages 1644 - 6
MASUDA Y. ET AL., CANCER CHEMOTHER PHARMACOL., vol. 42, no. 1, 1998, pages 9 - 16
WANG FS. ET AL., HUM GENE THER., vol. 10, no. 7, 1 May 1999 (1999-05-01), pages 1185 - 95
TSUJI, T. ET AL., BIOCHEMBIOPHYS RES COMMUN, vol. 268, 2000, pages 20 - 4
"Experimental Medicine, Separate Volume", BASIC TECHNOLOGY FOR GENE THERAPY, 1996
"Experimental Medicine, Separate Volume", GENE TRANSFER & EXPERIMENTAL METHODS FOR EXPRESSION ANALYSIS, 1997
MIYAKE, S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 93, 1996, pages 1320
LIEBER, A. ET AL., J. VIROL., vol. 70, 1996, pages 8944
MIZUGUCHI, H.; KAY, M. A., HUM. GENE THER., vol. 10, 1999, pages 2013
STEINWAERDER, D. S. ET AL., J. VIROL., vol. 73, 1999, pages 9303
RECCHIA, A. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 96, 1999, pages 2615
MIZUGUCHI, H.; HAYAKAWA, T., NIPPON RINSHO, vol. 7, 2000, pages 1544
GENE, vol. 108, 1991, pages 193 - 200
"NIKKEI SCIENCE", NIKKEI SCIENCE, vol. 36, no. 1, April 1994 (1994-04-01), pages 20 - 45
THE PHARMACEUTICALS MONTHLY, vol. 36, no. 1, 1994, pages 23 - 48
BAI L ET AL., INT J CANCER, vol. 53, 1993, pages 451 - 456
ABARZUA F ET AL., CANCER RES, vol. 65, 2005, pages 9617 - 9622
BELLOC F ET AL., CYTOMETRY, vol. 17, 1994, pages 59 - 65
MACIOROWSKI Z ET AL., CYTOMETRY, vol. 32, 1998, pages 44 - 50
BARZUA F ET AL., CANCER RES, vol. 65, 2005, pages 9617 - 9622
KUROSE K ET AL., ONCOGENE, vol. 171, 2004, pages 1314 - 13181
HSIEH SY, ONCOGENE, vol. 23, 2004, pages 9183 - 9189
BENNETT BL ET AL., PROC NATL ACAD SCI U.S.A., vol. 98, 2001, pages 13681 - 13686
ABARZUA F ET AL., INT J MOL MED, vol. 20, 2007, pages 37 - 43
TANIMOTO R ET AL., INT J MOL MED, vol. 19, 2007, pages 363 - 368
CUDNA RE, BIOTECHNOL BIOENG, vol. 81, 2003, pages 56 - 65
HERR I. ET AL., BLOOD, vol. 98, 2001, pages 2603 - 2614
UEDA K. ET AL., PROC NATL ACAD SCI U.S.A., vol. 84, 1987, pages 3004 - 3008
GIAI M. ET AL., EUR J GYNAECOL ONCOL, vol. 12, 1991, pages 35911 - 373
FUJITA T ET AL., INT J CANCER, vol. 117, 2005, pages 670 - 682
MIAO ZH ET AL., CANCER RES, vol. 63, 2003, pages 4527 - 4532
KIMIYA K. ET AL., J UROL., vol. 148, August 1992 (1992-08-01), pages 441 - 5
HASEGAWA S. ET AL., BR J CANCER., vol. 71, no. 5, May 1995 (1995-05-01), pages 907 - 13
Attorney, Agent or Firm:
HIRAKI, Yusuke et al. (3-20Toranomon 4-chome, Minato-ku, Tokyo 01, JP)
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