Title:
CANCER DNA ANALYSIS METHOD USING NEAR-FIELD AMPLIFICATION EFFECT OF THREE-DIMENSIONAL STRUCTURE METAMATERIAL SENSOR
Document Type and Number:
WIPO Patent Application WO/2019/074187
Kind Code:
A1
Abstract:
The present invention relates to a cancer DNA analysis method, wherein the onset of cancer can be quickly and accurately detected by analyzing a spectrum obtained by irradiating a sample including DNA with terahertz waves after applying the sample to a three-dimensional structure metamaterial sensor set to the terahertz natural frequency of DNA methylation which is a molecular-level cancer tumor marker, and the near-field amplification effect of the three-dimensional structure metamaterial sensor can be used to detect the cancer type with high sensitivity. A DNA analysis method is provided, the DNA analysis method comprising: (a) a step for irradiating with terahertz waves a DNA sample filling a three-dimensional structure metamaterial sensor having a predetermined resonance frequency; (b) a step for detecting terahertz waves transmitted through the DNA sample; and (c) a step for determining cancer type on the basis of the transmittance of the detected terahertz waves at the resonance frequency.
Inventors:
SON JOO-HIUK (KR)
LEE SANG-HUN (KR)
CHEON HWAYEONG (KR)
LEE SANG-HUN (KR)
CHEON HWAYEONG (KR)
Application Number:
PCT/KR2018/006904
Publication Date:
April 18, 2019
Filing Date:
June 19, 2018
Export Citation:
Assignee:
UNIV SEOUL IND COOP FOUND (KR)
International Classes:
C12Q1/6825; G01N21/3581; G01N29/12
Foreign References:
| KR20140007116A | 2014-01-17 | |||
| US20130130237A1 | 2013-05-23 | |||
| KR20140100135A | 2014-08-14 |
Other References:
CHEON, H. ET AL.: "Terahertz Molecular Resonance of Cancer DNA", SCIENTIFIC REPORTS, vol. 6, no. 37103, 15 November 2016 (2016-11-15), pages 1 - 10, XP055593567
ZHENG, N. ET AL.: "Metamaterial Sensor Platforms for Terahertz DNA Sensing", 2013 13TH IEEE INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY, 5 August 2013 (2013-08-05), pages 315 - 320, XP032559512
ZHENG, N. ET AL.: "Metamaterial Sensor Platforms for Terahertz DNA Sensing", 2013 13TH IEEE INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY, 5 August 2013 (2013-08-05), pages 315 - 320, XP032559512
Attorney, Agent or Firm:
PARK, Joonyong (KR)
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