Title:
CANCER-LIKE MUTANT
Document Type and Number:
WIPO Patent Application WO/2007/018182
Kind Code:
A1
Abstract:
An object of the invention is to provide a cancer-like mutant derived from a normal
gastric mucosal cell which is useful for screening an anticancer agent for stomach
cancer. The cancer-like mutant of the invention as a means for achieving the object
is prepared by transforming a normal gastric mucosal cell. The cancer-like mutant
of the invention can be prepared by, for example, culturing a normal gastric mucosal
cell in the presence of a carcinogen thereby to transform it.
Inventors:
MATSUI HIROFUMI (JP)
NAKAMURA YUMIKO (JP)
SHIMOKAWA OSAMU (JP)
MATSUZAKI YASUSHI (JP)
NAKAMURA YUMIKO (JP)
SHIMOKAWA OSAMU (JP)
MATSUZAKI YASUSHI (JP)
Application Number:
PCT/JP2006/315604
Publication Date:
February 15, 2007
Filing Date:
August 07, 2006
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
MATSUI HIROFUMI (JP)
NAKAMURA YUMIKO (JP)
SHIMOKAWA OSAMU (JP)
MATSUZAKI YASUSHI (JP)
MATSUI HIROFUMI (JP)
NAKAMURA YUMIKO (JP)
SHIMOKAWA OSAMU (JP)
MATSUZAKI YASUSHI (JP)
International Classes:
C12N5/00; C12N5/10; C12Q1/02; C12N15/01
Domestic Patent References:
| WO2004020656A1 | 2004-03-11 |
Foreign References:
| JP2003265195A | 2003-09-24 |
Other References:
WANG B. ET AL.: "Activation of proto-oncogenes induced by MNNG on primary culture of human gastric epithelium and immortalized human gastric epithelial cell line", ZHONGHUA ZHONG LIU ZA ZHI UCHINESE JOURNAL OF ONCOLOGY], vol. 18, no. 1, January 1996 (1996-01-01), pages 6 - 9, XP003008717
YANG H. ET AL.: "Experimental Study on Chronic Atrophic Gastritis Induced by Bile Reflux.", BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, vol. 24, no. 5, 2001, pages 29 - 33, XP003008718
MURATA H. ET AL.: "CagA ga Johi Saibo no Apoptosis ni Ataeru Eikyo", HERICOBACTER RESEARCH, vol. 8, no. 4, 2004, pages 309 - 314, XP003008719
WAHBY M. ET AL.: "Induction of gastric mucosal cell proliferation by the fungicide captan role of tyrosine kinases", TOXICOLOGY LETTERS (SHANNON), vol. 54, no. 2-3, 1990, pages 189 - 198, XP003008720
FUKUSHIMA A.: "Shokaki Hatsugan no Shushoku Yoin Koseisho Gan Kenkyu Joseikin ni yoru Kenkyu Hokokushu", vol. 1987, 1988, pages 228 - 232, XP003008721
YUASA H. ET AL.: "Expression of cathepsin E and its suppression with intestinalization in epithelial cells and tumor cells in rat glandular stomach treated with N-methyl-N'-nitro-N-nitrosoguanidine", J. TOXICOL. PATHOL., vol. 14, no. 1, 2001, pages 29 - 35, XP003008722
DEAN B.J. ET AL.: "An in vitro chromosome assay using cultured rat-liver cells", MUTAT. RES., vol. 64, no. 5, 1979, pages 329 - 337, XP003008723
NAKASHO K. ET AL.: "Taishi Rat Yurai no Hishuyosei Kanjohi Saibokabu "FRLE" no N-Methyl-N'-Nitro-N-Nitrosoguanidine(MNNG) ni yoru Ganka Yudo", ACTA MEDICA HYOGOENSIA, vol. 18, no. 3, 1993, pages 165 - 175, XP003008724
SOMMER E.W. ET AL.: "A chemically transformed rat fibroblast cell line expresses high levels of oncomodulin", FEBS LETT., vol. 257, no. 2, 6 November 1989 (1989-11-06), pages 307 - 310, XP003008725
GILLETT N.A. ET AL.: "Cell-line-dependent inhibition of phenotypic expression of preneoplastic and neoplastic tracheal epithelial cells by normal tracheal cells in denuded tracheal transplants", CARCINOGENESIS, vol. 10, no. 7, July 1989 (1989-07-01), pages 1147 - 1154, XP003008726
YANG H. ET AL.: "Experimental Study on Chronic Atrophic Gastritis Induced by Bile Reflux.", BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE, vol. 24, no. 5, 2001, pages 29 - 33, XP003008718
MURATA H. ET AL.: "CagA ga Johi Saibo no Apoptosis ni Ataeru Eikyo", HERICOBACTER RESEARCH, vol. 8, no. 4, 2004, pages 309 - 314, XP003008719
WAHBY M. ET AL.: "Induction of gastric mucosal cell proliferation by the fungicide captan role of tyrosine kinases", TOXICOLOGY LETTERS (SHANNON), vol. 54, no. 2-3, 1990, pages 189 - 198, XP003008720
FUKUSHIMA A.: "Shokaki Hatsugan no Shushoku Yoin Koseisho Gan Kenkyu Joseikin ni yoru Kenkyu Hokokushu", vol. 1987, 1988, pages 228 - 232, XP003008721
YUASA H. ET AL.: "Expression of cathepsin E and its suppression with intestinalization in epithelial cells and tumor cells in rat glandular stomach treated with N-methyl-N'-nitro-N-nitrosoguanidine", J. TOXICOL. PATHOL., vol. 14, no. 1, 2001, pages 29 - 35, XP003008722
DEAN B.J. ET AL.: "An in vitro chromosome assay using cultured rat-liver cells", MUTAT. RES., vol. 64, no. 5, 1979, pages 329 - 337, XP003008723
NAKASHO K. ET AL.: "Taishi Rat Yurai no Hishuyosei Kanjohi Saibokabu "FRLE" no N-Methyl-N'-Nitro-N-Nitrosoguanidine(MNNG) ni yoru Ganka Yudo", ACTA MEDICA HYOGOENSIA, vol. 18, no. 3, 1993, pages 165 - 175, XP003008724
SOMMER E.W. ET AL.: "A chemically transformed rat fibroblast cell line expresses high levels of oncomodulin", FEBS LETT., vol. 257, no. 2, 6 November 1989 (1989-11-06), pages 307 - 310, XP003008725
GILLETT N.A. ET AL.: "Cell-line-dependent inhibition of phenotypic expression of preneoplastic and neoplastic tracheal epithelial cells by normal tracheal cells in denuded tracheal transplants", CARCINOGENESIS, vol. 10, no. 7, July 1989 (1989-07-01), pages 1147 - 1154, XP003008726
Attorney, Agent or Firm:
SHIMIZU, Yoshihiro et al. (Yashiro Building 14-4, Takadanobaba 2-chome, Shinjuku-k, Tokyo 75, JP)
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