Title:
CANCER THERAPY SENSITIZER
Document Type and Number:
WIPO Patent Application WO2004064785
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for sensitizing cancer therapy. The invention provides such compositions comprising a SPARC family polypeptide or polynucleotide, as well as recombinant cells containing a SPARC family polypeptide or polynucleotide. The compositions and methods of the invention are useful in in vitro study of cancer therapy resistance, as well as ex vivo and in vivo therapy of cancer. Figure 1 is a modular structure of human SPARC and the location and functions of synthetic peptides.
Inventors:
TAI ISABELLE T (CA)
CHEN LAN BO (US)
CHEN LAN BO (US)
Application Number:
PCT/US2004/000901
Publication Date:
October 20, 2005
Filing Date:
January 14, 2004
Export Citation:
Assignee:
DANA FARBER CANCER INST INC (US)
TAI ISABELLE T (CA)
CHEN LAN BO (US)
TAI ISABELLE T (CA)
CHEN LAN BO (US)
International Classes:
A01N61/00; A61K6/00; A61K31/00; A61K31/7088; A61K38/17; A61K38/39; A61K45/06; A61K48/00; A61P35/00; C07K1/00; C12N5/10; C12Q1/68; G01N33/50; A61K; (IPC1-7): A01N61/00; A61K31/00; C07K1/00
Foreign References:
| US20030082228A1 | 2003-05-01 | |||
| US6406693B1 | 2002-06-18 | |||
| US6475784B1 | 2002-11-05 |
Other References:
YIU G.K. ET AL: "SPARC (Secreted Protein Acidic and Rich in Cysteine) Induces Apoptosis in Ovarian Cancer Cells", AM J PATHOL, vol. 159, no. 2, August 2001 (2001-08-01), pages 609 - 662, XP002983766
CHLENSKI A. ET AL: "SPARC Is a Key Schwannian-derived Inhibitor Controlling Neuroblastoma Tumor Angiogenesis", CANCER RES, vol. 62, 15 December 2002 (2002-12-15), pages 7357 - 7363, XP002986916
See also references of EP 1594433A4
CHLENSKI A. ET AL: "SPARC Is a Key Schwannian-derived Inhibitor Controlling Neuroblastoma Tumor Angiogenesis", CANCER RES, vol. 62, 15 December 2002 (2002-12-15), pages 7357 - 7363, XP002986916
See also references of EP 1594433A4
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