Title:
CANCER TREATMENT BY COMBINED USE OF EP4 ANTAGONIST AND IMMUNE CHECKPOINT INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2022/102731
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an effective cancer treatment method. The present invention provides a cancer treatment method that combines a standard treatment with an EP4 antagonist and an immune checkpoint inhibitor (e.g., an anti-PD-1 antibody). The treatment method according to the present invention is useful in cancer treatment.
Inventors:
KONDO MAKI (JP)
Application Number:
PCT/JP2021/041650
Publication Date:
May 19, 2022
Filing Date:
November 12, 2021
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
A61K31/353; A61K31/282; A61K31/337; A61K31/513; A61K31/519; A61K31/7068; A61K39/395; A61K45/00; A61P1/00; A61P35/00; A61P35/04; A61P37/04; A61P43/00
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EDWARD B GARON, TUDOR-ELIADE CIULEANU, OSCAR ARRIETA, KUMAR PRABHASH, KONSTANTINOS N SYRIGOS, TUNCAY GOKSEL, KEUNCHIL PARK, VERA G: "Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial", THE LANCET, ¬J.B. FLINT|, vol. 384, no. 9944, 1 August 2014 (2014-08-01), pages 665 - 673, XP055184786, ISSN: 01406736, DOI: 10.1016/S0140-6736(14)60845-X
YOH, TOMOAKI: "A Case of Effective Neoadjuvant Chemoradiotherapy with Capecitabine for Locally Advanced Sigmoid Colon Cancer", JAPANESE JOURNAL OF CANCER AND CHEMOTHERAPY, vol. 38, no. 6, 1 January 2011 (2011-01-01), JP , pages 1021 - 1024, XP009536660, ISSN: 0385-0684
JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING, vol. 12, 1995, pages 379 - 391
PHARMACOLOGICAL REVIEWS, vol. 65, July 2013 (2013-07-01), pages 1010 - 1052
"105th Annual Meeting of American Association for Cancer Research (AACR), Abstract: LB-265", TITLE OF PRESENTATION: ONO-AE3-208 INHIBITS MYELOID DERIVED SUPPRESSOR CELLS AND GLIOMA GROWTH, DATE OF PRESENTATION, 8 April 2014 (2014-04-08)
FEBS LETTERS, vol. 364, 1995, pages 339 - 341
CANCER SCIENCE, vol. 105, 2014, pages 1142 - 1151
CANCER RESEARCH, vol. 70, 2010, pages 1606 - 1615
CANCER RESEARCH, vol. 62, 2002, pages 28 - 32
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NATURE REVIEWS CANCER, vol. 12, 2012, pages 252 - 264
CANCER CELL, vol. 27, 2015, pages 450 - 461
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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