CANCER VACCINE PREPARATION

Title:

CANCER VACCINE PREPARATION

Document Type and Number:

WIPO Patent Application WO/2006/077724

Kind Code:

A1

Abstract:

[PROBLEMS] To overcome problems that conventional cancer vaccines can only activate killer T cells or can only activate killer T cells and helper T cells and that there is no practically useful cancer vaccine preparation which is capable of activating antigen-presenting cells as well. [MEANS FOR SOLVING PROBLEMS] A preparation comprising a combination of a complex of a cancer antigen and a hydrophobized polysaccharide with a antigen-presenting cell-stimulating agent which is capable of binding to a Toll-like receptor can activate all of antigen-presenting cells, killer T cells and helper T cells (all of which are major cells involved in the induction and activation of antigen-specific immunity against cancer cells) to exhibit a potent vaccinal effect. The vaccine preparation can evoke immune response to cancer antigens, and particularly has effects of activation and induction of cytotoxic T cells and helper T cells. Therefore, the vaccine preparation can be used as a vaccine for treatment or prevention of cancer.

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Inventors:

SHIKU HIROSHI (JP)
KAGEYAMA SHIN-ICHI (JP)

Application Number:

PCT/JP2005/023905

Publication Date:

July 27, 2006

Filing Date:

December 27, 2005

Export Citation:

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Assignee:

MIE TLO CO LTD (JP)
SHIKU HIROSHI (JP)
KAGEYAMA SHIN-ICHI (JP)

International Classes:

A61K39/39; A61K9/16; A61K31/7088; A61K35/74; A61K39/00; A61K45/00; A61K47/36; A61P35/00

Domestic Patent References:

WO1998009650A1	1998-03-12
WO2003045431A2	2003-06-05

Other References:

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