Title:
CANCER VACCINE USING COMMON CANCER ANTIGEN COCKTAIL, TCR/CAR-T CELL THERAPEUTIC, COMPANION DIAGNOSTIC METHOD, AND METHOD FOR DIAGNOSING CANCER ONSET RISK BY BLOOD-CIRCULATING CANCER CELL DETECTION
Document Type and Number:
WIPO Patent Application WO/2023/224096
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a cancer vaccine that uses a common cancer antigen cocktail, a TCR/CAR-T cell therapeutic, a companion diagnostic method, and a method for diagnosing cancer onset risk by blood-circulating cancer cell detection. The present invention provides a cancer vaccine that includes (1) common cancer antigens including 3 or more of GPC3, ROBO1, EPHB4, CLDN1, and LAT1, (2) partial peptides of the 3 or more common cancer antigens that have CTL inducibility, (3) dendritic cells stimulated by the partial peptides, or (4) mRNA that codes for the common cancer antigens or the partial peptides.
Inventors:
NAKATSURA TETSUYA (JP)
TAKENOUCHI KAZUMASA (JP)
TSUKAMOTO NOBUO (JP)
SHIMOMURA MANAMI (JP)
SUZUKI TOSHIHIRO (JP)
TAKENOUCHI KAZUMASA (JP)
TSUKAMOTO NOBUO (JP)
SHIMOMURA MANAMI (JP)
SUZUKI TOSHIHIRO (JP)
Application Number:
PCT/JP2023/018618
Publication Date:
November 23, 2023
Filing Date:
May 18, 2023
Export Citation:
Assignee:
NAT CANCER CT (JP)
International Classes:
A61K38/08; A61K39/00; A61K38/10; A61P35/00; A61P37/04; C07K14/725; C12N5/0784
Domestic Patent References:
| WO2020245264A1 | 2020-12-10 | |||
| WO2007018198A1 | 2007-02-15 | |||
| WO2007018199A1 | 2007-02-15 |
Foreign References:
| JP2016528221A | 2016-09-15 | |||
| JP2006519610A | 2006-08-31 |
Other References:
CHARNEAU JIMMY, SUZUKI TOSHIHIRO, SHIMOMURA MANAMI, FUJINAMI NORIHIRO, NAKATSURA TETSUYA: "Peptide-Based Vaccines for Hepatocellular Carcinoma: A Review of Recent Advances", JOURNAL OF HEPATOCELLULAR CARCINOMA 2014, vol. Volume 8, 1 September 2021 (2021-09-01), pages 1035 - 1054, XP093109383, ISSN: 2253-5969, DOI: 10.2147/JHC.S291558
TOSHIYASU SHIMIZU ET AL.: "Development of cancer immunotherapy targeting amino acid transporter L-type amino acid transporter-1 (LAT1)", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN (CD-ROM), PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 131, no. 3, 1 January 2011 (2011-01-01), JP , pages 155, XP009550526, ISSN: 0918-9823
MITSUHIRO INOUE ET AL.: "HP-207-4 Development of cancer immunotherapy targeting the novel cancer-related antigen SPARC", NIHON GEKA GAKKAI ZASSHI = JOURNAL OF JAPAN SURGICAL SOCIETY ; JJSS, JAPAN SURGICAL SOCIETY, JP, vol. 110, no. Spec. Extra Ed. 2, 1 January 2009 (2009-01-01), JP , pages 738, XP009550521, ISSN: 1880-1129
SHIMIZU YASUHIRO, SUZUKI TOSHIHIRO, YOSHIKAWA TOSHIAKI, ENDO ITARU, NAKATSURA TETSUYA: "Next-Generation Cancer Immunotherapy Targeting Glypican-3", FRONTIERS IN ONCOLOGY, vol. 9, 10 April 2019 (2019-04-10), pages 1 - 10, XP093042894, DOI: 10.3389/fonc.2019.00248
TOSHIYASU SHIMIZU ET AL.: "Development of cancer immunotherapy targeting amino acid transporter L-type amino acid transporter-1 (LAT1)", ABSTRACTS OF ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN (CD-ROM), PHARMACEUTICAL SOCIETY OF JAPAN, JP, vol. 131, no. 3, 1 January 2011 (2011-01-01), JP , pages 155, XP009550526, ISSN: 0918-9823
MITSUHIRO INOUE ET AL.: "HP-207-4 Development of cancer immunotherapy targeting the novel cancer-related antigen SPARC", NIHON GEKA GAKKAI ZASSHI = JOURNAL OF JAPAN SURGICAL SOCIETY ; JJSS, JAPAN SURGICAL SOCIETY, JP, vol. 110, no. Spec. Extra Ed. 2, 1 January 2009 (2009-01-01), JP , pages 738, XP009550521, ISSN: 1880-1129
SHIMIZU YASUHIRO, SUZUKI TOSHIHIRO, YOSHIKAWA TOSHIAKI, ENDO ITARU, NAKATSURA TETSUYA: "Next-Generation Cancer Immunotherapy Targeting Glypican-3", FRONTIERS IN ONCOLOGY, vol. 9, 10 April 2019 (2019-04-10), pages 1 - 10, XP093042894, DOI: 10.3389/fonc.2019.00248
Attorney, Agent or Firm:
SIKS & CO. (JP)
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