Title:
CAPPED OLIGOSACCHARIDES COMPRISING SEVEN OR MORE UNITS OF 4,6-DIDEOXY-4-ACYLAMIDO-ALPHA-PYRANOSE AND CONJUGATES THEREOF AS VACCINES AGAINST INFECTIONS CAUSED BY BRUCELLA ORGANISMS
Document Type and Number:
WIPO Patent Application WO/2018/083490
Kind Code:
A3
Abstract:
There is provided a molecule comprising a chain of seven or more contiguous units of 4,6-dideoxy-4-acylamido-α-pyranose, each pair of units joined by a C1-C2 or a C1-C3 link, the chain having a terminal end and a reducing end, wherein the pyranose ring in the unit of the chain most distal from the reducing end is linked to a cap structure. The cap structure is not a 4,6-dideoxy-4-acylamido-α-pyranose. There are also provided vaccine compositions comprising the molecule and methods of vaccinating an animal against infection by a Brucella organism, including methods of distinguishing between a vaccinated and an infected animal. There are further provided novel methods of detecting the presence in a sample of an anti-Brucella antibody.
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Inventors:
MCGIVEN JOHN (GB)
HOWELLS LAURENCE (GB)
DUNCOMBE LUCY (GB)
BUNDLE DAVID (CA)
MANDAL SATADRU SEKHAR (CA)
SARKAR SUSMITA (CA)
HOWELLS LAURENCE (GB)
DUNCOMBE LUCY (GB)
BUNDLE DAVID (CA)
MANDAL SATADRU SEKHAR (CA)
SARKAR SUSMITA (CA)
Application Number:
PCT/GB2017/053322
Publication Date:
August 09, 2018
Filing Date:
November 03, 2017
Export Citation:
Assignee:
THE SEC DEP FOR ENVIRONMENT FOOD AND RURAL AFFAIRS (GB)
UNIV ALBERTA (CA)
UNIV ALBERTA (CA)
International Classes:
C07H5/06; C07H15/18; G01N33/53
Domestic Patent References:
| WO2014170681A2 | 2014-10-23 |
Other References:
N. VIJAYA GANESH ET AL: "Molecular Recognition of Brucella A and M Antigens Dissected by Synthetic Oligosaccharide Glycoconjugates Leads to a Disaccharide Diagnostic for Brucellosis", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 46, 19 November 2014 (2014-11-19), US, pages 16260 - 16269, XP055451497, ISSN: 0002-7863, DOI: 10.1021/ja5081184
JULIE GUIARD ET AL: "Design and Synthesis of a Universal Antigen to Detect Brucellosis", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 52, no. 28, 8 July 2013 (2013-07-08), pages 7181 - 7185, XP055128620, ISSN: 1433-7851, DOI: 10.1002/anie.201302303
YUJI OGAWA ET AL: "Synthesis of the dodecasaccharide fragment representing the O-polysaccharide of Vibrio cholerae O:1, serotype Ogawa, bearing an aglycon offering flexibility for chemical linking to proteins", GLYCOCONJUGATE JOURNAL, 1 June 1997 (1997-06-01), Boston, pages 433 - 438, XP055451504, Retrieved from the Internet DOI: 10.1023/A:1018591132723
SATADRU SEKHAR MANDAL ET AL: "Novel Solutions for Vaccines and Diagnostics To Combat Brucellosis", ACS CENTRAL SCIENCE, vol. 3, no. 3, 3 March 2017 (2017-03-03), pages 224 - 231, XP055451498, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00019
SATADRU SEKHAR MANDAL ET AL: "Synthetic glycoconjugates characterize the fine specificity of Brucella A and M monoclonal antibodies", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 15, no. 18, 14 May 2017 (2017-05-14), pages 3874 - 3883, XP055486227, ISSN: 1477-0520, DOI: 10.1039/C7OB00445A
JULIE GUIARD ET AL: "Design and Synthesis of a Universal Antigen to Detect Brucellosis", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 52, no. 28, 8 July 2013 (2013-07-08), pages 7181 - 7185, XP055128620, ISSN: 1433-7851, DOI: 10.1002/anie.201302303
YUJI OGAWA ET AL: "Synthesis of the dodecasaccharide fragment representing the O-polysaccharide of Vibrio cholerae O:1, serotype Ogawa, bearing an aglycon offering flexibility for chemical linking to proteins", GLYCOCONJUGATE JOURNAL, 1 June 1997 (1997-06-01), Boston, pages 433 - 438, XP055451504, Retrieved from the Internet
SATADRU SEKHAR MANDAL ET AL: "Novel Solutions for Vaccines and Diagnostics To Combat Brucellosis", ACS CENTRAL SCIENCE, vol. 3, no. 3, 3 March 2017 (2017-03-03), pages 224 - 231, XP055451498, ISSN: 2374-7943, DOI: 10.1021/acscentsci.7b00019
SATADRU SEKHAR MANDAL ET AL: "Synthetic glycoconjugates characterize the fine specificity of Brucella A and M monoclonal antibodies", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 15, no. 18, 14 May 2017 (2017-05-14), pages 3874 - 3883, XP055486227, ISSN: 1477-0520, DOI: 10.1039/C7OB00445A
Attorney, Agent or Firm:
TURNER, Rhiannon (GB)
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