Title:
CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2006/030807
Kind Code:
A1
Abstract:
A compound represented by the formula (I), which has antiviral activity, especially HIV integrase inhibitory activity, a pharmaceutically acceptable salt of the compound, or a solvate of either; and a medicine, especially an anti-HIV drug, which contains the compound, salt, or solvate. (In the formula, Y is NR4 (R4 is hydrogen, etc.), O, S, SO, or SO2; RA is (1) a group represented by the formula -COR5 (R5 is a group selected among substituents (A)) or (2) a group represented by the formula (wherein ring C is an optionally substituted, nitrogenous aromatic heterocycle in which at least one of the atoms adjacent to the atom having a bond for external linkage is an unsubstituted nitrogen atom; and the broken line indicates the presence or absence of a bond); R1 is hydrogen, etc.; X is a single bond, etc.; R2 is a group selected among substituents (A); and R3 is hydrogen, etc.; provided that the substituents (A) are hydrogen, hydroxy, optionally substituted lower alkyls, etc.)
Inventors:
YOSHIDA HIROSHI (JP)
Application Number:
PCT/JP2005/016904
Publication Date:
March 23, 2006
Filing Date:
September 14, 2005
Export Citation:
Assignee:
SHIONOGI & CO (JP)
YOSHIDA HIROSHI (JP)
YOSHIDA HIROSHI (JP)
International Classes:
C07D213/82; A61K31/366; A61K31/4436; A61K31/4439; A61K31/455; A61K31/506; A61K31/5377; A61P31/14; A61P31/18; C07D309/38; C07D401/12; C07D405/04; C07D409/12; C07D413/04; C07D417/04
Domestic Patent References:
| WO2003016275A1 | 2003-02-27 | |||
| WO2004004657A2 | 2004-01-15 | |||
| WO2003035076A1 | 2003-05-01 | |||
| WO2000039086A1 | 2000-07-06 | |||
| WO2004024693A1 | 2004-03-25 | |||
| WO2005042524A1 | 2005-05-12 |
Foreign References:
| JP2004244320A | 2004-09-02 | |||
| JPH02108668A | 1990-04-20 | |||
| JPH02108683A | 1990-04-20 | |||
| EP1544199A1 | 2005-06-22 |
Other References:
TEWTRAKUL S ET AL: "Flavanone and Flavonol Glycosides from the Leaves of Thevetia peruviana and Their HIV-1 Reverse Transcriptase and HIV-1 Integrase Inhibitory Activities.", CHEM PHARM BULL., vol. 50, no. 5, 2002, pages 630 - 635, XP002993094
Attorney, Agent or Firm:
Yamauchi, Hideaki (Ltd. Intellectual Property Department 12-4
Sagisu 5-chome, Fukushima-k, Osaka-shi Osaka 02, JP)
Download PDF:
Previous Patent: PURINENUCLEOSIDE DERIVATIVE MODIFIED IN 8-POSITION AND MEDICINAL USE THEREOF
Next Patent: SOFTWARE GENERATING METHOD
Next Patent: SOFTWARE GENERATING METHOD