Title:
CARBAPENEM ANTIBIOTIC-TOLERANT PATHOGENIC BACTERIUM FLUORESCENT PROBE AND SYNTHESIS METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/130158
Kind Code:
A9
Abstract:
Disclosed in the present invention is a carbapenem antibiotic-tolerant pathogenic bacterium fluorescent probe with a structural general formula as represented by general formula I. The synthesis method for the fluorescent probe comprises the steps of: (1) preparation of a compound 3; (2) preparation of a compound 4; and (3) preparation of a fluorescent probe CVB-1. The fluorescent probe can be made into a test paper, kits or detection chips to be applied to the detection of carbapenemases and carbapenem drug-tolerant bacteria. Carbapenemases are detected or distinguished by determining whether the fluorescence intensity or colour of the fluorescent probe changes or not, and accordingly, pathogenic drug-tolerant bacteria expressing carbapenemases can be detected rapidly. The fluorescent probe guides the reasonable utilization of antibiotic drugs in terms of treatment or clinical application, and has important significance in terms of using no or less antibiotic drugs.
Inventors:
XIE HEXIN (CN)
MAO WUYU (CN)
XIA LINGYING (CN)
MAO WUYU (CN)
XIA LINGYING (CN)
Application Number:
PCT/CN2018/072128
Publication Date:
November 22, 2018
Filing Date:
January 10, 2018
Export Citation:
Assignee:
UNIV EAST CHINA SCIENCE & TECH (CN)
International Classes:
C09K11/06; C07D477/14; C12Q1/06; C12Q1/34; G01N21/64
Attorney, Agent or Firm:
SHANGHAI ESSEN PATEN & TRADEMARK AGENCY (CN)
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