Title:
CARBAPENEM DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/1999/031106
Kind Code:
A1
Abstract:
Compounds represented by general formula (I); a process for producing the same; and utilization thereof as antimicrobial agents and metallo-$g(b)-lactamase inhibitors, wherein R?1¿ represents hydrogen or lower alkyl; R?2¿ represents hydrogen, an ester residue, etc.; R?3¿ and R?4¿ are the same or different and each represents hydrogen, halogeno, etc.; R?5¿ and R?6¿ are the same or different and each represents hydrogen, lower alkoxy, etc., or lower alkyl optionally having one or two substituents selected from the group consisting of carbamoyl, carboxy and hydroxy; group (a) represents aryl selected from the group consisting of benzene and naphthalene rings, etc.; and Y represents a single bond, linear C¿1-4? alkylene, etc. (provided that the case where R?3¿ and R?4¿ are hydrogen, (a) is benzene, Y is methylene and R?5¿ and R?6¿ are hydrogen is excluded).
Inventors:
NAKANO MASATO (JP)
KIYONAGA HIDEO (JP)
IMAMURA HIDEAKI (JP)
SHIMIZU AYA (JP)
SATO HIROKI (JP)
SUGIMOTO YUICHI (JP)
SAKURABA SHUNJI (JP)
NAKAGAWA SUSUMU (JP)
FUKATSU HIROSHI (JP)
USHIJIMA RYOSUKE (JP)
HASHIZUME TERUTAKA (JP)
NAGANO RIE (JP)
KIYONAGA HIDEO (JP)
IMAMURA HIDEAKI (JP)
SHIMIZU AYA (JP)
SATO HIROKI (JP)
SUGIMOTO YUICHI (JP)
SAKURABA SHUNJI (JP)
NAKAGAWA SUSUMU (JP)
FUKATSU HIROSHI (JP)
USHIJIMA RYOSUKE (JP)
HASHIZUME TERUTAKA (JP)
NAGANO RIE (JP)
Application Number:
PCT/JP1998/005694
Publication Date:
June 24, 1999
Filing Date:
December 16, 1998
Export Citation:
Assignee:
BANYU PHARMA CO LTD (JP)
NAKANO MASATO (JP)
KIYONAGA HIDEO (JP)
IMAMURA HIDEAKI (JP)
SHIMIZU AYA (JP)
SATO HIROKI (JP)
SUGIMOTO YUICHI (JP)
SAKURABA SHUNJI (JP)
NAKAGAWA SUSUMU (JP)
FUKATSU HIROSHI (JP)
USHIJIMA RYOSUKE (JP)
HASHIZUME TERUTAKA (JP)
NAGANO RIE (JP)
NAKANO MASATO (JP)
KIYONAGA HIDEO (JP)
IMAMURA HIDEAKI (JP)
SHIMIZU AYA (JP)
SATO HIROKI (JP)
SUGIMOTO YUICHI (JP)
SAKURABA SHUNJI (JP)
NAKAGAWA SUSUMU (JP)
FUKATSU HIROSHI (JP)
USHIJIMA RYOSUKE (JP)
HASHIZUME TERUTAKA (JP)
NAGANO RIE (JP)
International Classes:
C07D477/20; (IPC1-7): C07D477/20; A61K31/40
Domestic Patent References:
| WO1995023150A1 | 1995-08-31 |
Foreign References:
| JPH04321688A | 1992-11-11 | |||
| JPH04134082A | 1992-05-07 | |||
| JPS63170379A | 1988-07-14 | |||
| JPS58118588A | 1983-07-14 | |||
| JPS58891A | 1983-01-06 | |||
| JPS57108091A | 1982-07-05 |
Attorney, Agent or Firm:
BANYU PHARMACEUTICAL CO., LTD. (2-3 Nihombashi Honcho 2-chome Chuo-ku Tokyo, JP)
BANYU PHARMACEUTICAL CO., LTD. (2-3 Nihombashi Honcho 2-chome Chuo-ku Tokyo, JP)
BANYU PHARMACEUTICAL CO., LTD. (2-3 Nihombashi Honcho 2-chome Chuo-ku Tokyo, JP)
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