Title:
CARBAZOLE DERIVATIVES FOR TREATING POLYCYSTIC KIDNEY DISEASE
Document Type and Number:
WIPO Patent Application WO2006012310
Kind Code:
A3
Abstract:
Compounds represented by Structural Formula (I): where X is -H, -OR, -SH, -OC(O)R, -OC(O)OR,-OC(O)NRR or -SC(O)OR have anti-cystogenic activity, particularly against polycystic kidney disease. Such compounds can be used in pharmaceutical compounds and in methods of treating polycystic kidney diseases. The invention also includes novel 3-hydroxymethyl-substituted carbazoles and compounds of Structural Formula (I) where Ring A is a 5-, 6-, 7- or 8- membered non-aromatic carbocyclic ring optionally substituted at one or more substitutable ring atoms.
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Inventors:
SNEDDON SCOTT F (US)
BESKROVNAYA OXANA (US)
GREGORY JILL S (US)
SMITH LAURIE ANN (US)
HUSSON HERVE (US)
BUKANOV NIKOLAI O (US)
YEE CHRISTOPHER (US)
HIRTH BRADFORD H (US)
CUFF LISA M (US)
JANJIGIAN ANDREW (US)
JOZEFIAK THOMAS H (US)
BASTOS CECILIA M (US)
HILMY AHMED (US)
SKELL JEFFREY (US)
GIRAGOSSIAN CRAIG (US)
COCHRAN BRIAN (US)
SERRANO MONICA (US)
BESKROVNAYA OXANA (US)
GREGORY JILL S (US)
SMITH LAURIE ANN (US)
HUSSON HERVE (US)
BUKANOV NIKOLAI O (US)
YEE CHRISTOPHER (US)
HIRTH BRADFORD H (US)
CUFF LISA M (US)
JANJIGIAN ANDREW (US)
JOZEFIAK THOMAS H (US)
BASTOS CECILIA M (US)
HILMY AHMED (US)
SKELL JEFFREY (US)
GIRAGOSSIAN CRAIG (US)
COCHRAN BRIAN (US)
SERRANO MONICA (US)
Application Number:
PCT/US2005/022524
Publication Date:
August 10, 2006
Filing Date:
June 23, 2005
Export Citation:
Assignee:
GENZYME CORP (US)
SNEDDON SCOTT F (US)
BESKROVNAYA OXANA (US)
GREGORY JILL S (US)
SMITH LAURIE ANN (US)
HUSSON HERVE (US)
BUKANOV NIKOLAI O (US)
YEE CHRISTOPHER (US)
HIRTH BRADFORD H (US)
CUFF LISA M (US)
JANJIGIAN ANDREW (US)
JOZEFIAK THOMAS H (US)
BASTOS CECILIA M (US)
HILMY AHMED (US)
SKELL JEFFREY (US)
GIRAGOSSIAN CRAIG (US)
COCHRAN BRIAN (US)
SERRANO MONICA (US)
SNEDDON SCOTT F (US)
BESKROVNAYA OXANA (US)
GREGORY JILL S (US)
SMITH LAURIE ANN (US)
HUSSON HERVE (US)
BUKANOV NIKOLAI O (US)
YEE CHRISTOPHER (US)
HIRTH BRADFORD H (US)
CUFF LISA M (US)
JANJIGIAN ANDREW (US)
JOZEFIAK THOMAS H (US)
BASTOS CECILIA M (US)
HILMY AHMED (US)
SKELL JEFFREY (US)
GIRAGOSSIAN CRAIG (US)
COCHRAN BRIAN (US)
SERRANO MONICA (US)
International Classes:
A61K31/403; A61K31/4439; A61K31/497; A61K31/5377; A61P13/12; C07D205/06; C07D209/80; C07D209/86; C07D209/88; C07D401/06; C07D491/04
Domestic Patent References:
| WO2002042250A1 | 2002-05-30 | |||
| WO2001012603A1 | 2001-02-22 | |||
| WO2004063156A1 | 2004-07-29 | |||
| WO2005005386A1 | 2005-01-20 | |||
| WO2005023245A1 | 2005-03-17 | |||
| WO2004110999A1 | 2004-12-23 | |||
| WO2005037791A1 | 2005-04-28 |
Foreign References:
| US4174402A | 1979-11-13 | |||
| US5451600A | 1995-09-19 | |||
| US3959309A | 1976-05-25 | |||
| US3832172A | 1974-08-27 | |||
| EP0310179A2 | 1989-04-05 |
Other References:
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UTLEY, JAMES H. P. ET AL: "Preparation of a series of 3- and 6-substituted 1,2,3,4-tetra- and 1,2,3,4,4a,9a-hexa-hydrocarbazoles", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999) , (8), 888-92 CODEN: JCPRB4; ISSN: 0300-922X, 1978, XP008058182
BRUCK, PETER: "Indoles, carbazoles, and related compounds. I. Carbazole leuco derivatives related to 4,4'-diaminodiphenylmethanes. Bis(3- carbazolyl)methanes and bis(9-carbazolyl) methanes", JOURNAL OF ORGANIC CHEMISTRY , 35(7), 2222-7 CODEN: JOCEAH; ISSN: 0022-3263, 1970, XP002383914
DAVIES D J ET AL: "Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 4, 1998, pages 451 - 467, XP002215114, ISSN: 0022-2623
CHAKRABORTY, DEBI P. ET AL: "Synthesis of murrayacine", JOURNAL OF ORGANIC CHEMISTRY , 38(15), 2728-9 CODEN: JOCEAH; ISSN: 0022-3263, 1973, XP002383915
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1965, LOPATINSKII, V. P. ET AL: "Study of the chemistry of carbazole derivatives. XV. Syntheses and conversions of some acetyl derivatives of 9-alkylcarbazoles", XP002383917, retrieved from STN Database accession no. 1965:403222
LOPATINSKII, V. P. ET AL: "Chemistry of carbazole derivatives. XIV. The reduction of 3,6-diacetyl-9-methyl- and 3,6-diacetyl-9-ethylcarbazoles with aluminum isopropoxide", IZVESTIYA TOMSKOGO POLITEKHNICHESKOGO INSTITUTA , 126, 67-9 CODEN: ITPKAM; ISSN: 0368-0487, 1964, XP008058168
UTLEY, JAMES H. P. ET AL: "Preparation of a series of 3- and 6-substituted 1,2,3,4-tetra- and 1,2,3,4,4a,9a-hexa-hydrocarbazoles", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1: ORGANIC AND BIO-ORGANIC CHEMISTRY (1972-1999) , (8), 888-92 CODEN: JCPRB4; ISSN: 0300-922X, 1978, XP008058182
BRUCK, PETER: "Indoles, carbazoles, and related compounds. I. Carbazole leuco derivatives related to 4,4'-diaminodiphenylmethanes. Bis(3- carbazolyl)methanes and bis(9-carbazolyl) methanes", JOURNAL OF ORGANIC CHEMISTRY , 35(7), 2222-7 CODEN: JOCEAH; ISSN: 0022-3263, 1970, XP002383914
DAVIES D J ET AL: "Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 41, no. 4, 1998, pages 451 - 467, XP002215114, ISSN: 0022-2623
CHAKRABORTY, DEBI P. ET AL: "Synthesis of murrayacine", JOURNAL OF ORGANIC CHEMISTRY , 38(15), 2728-9 CODEN: JOCEAH; ISSN: 0022-3263, 1973, XP002383915
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1965, LOPATINSKII, V. P. ET AL: "Study of the chemistry of carbazole derivatives. XV. Syntheses and conversions of some acetyl derivatives of 9-alkylcarbazoles", XP002383917, retrieved from STN Database accession no. 1965:403222
LOPATINSKII, V. P. ET AL: "Chemistry of carbazole derivatives. XIV. The reduction of 3,6-diacetyl-9-methyl- and 3,6-diacetyl-9-ethylcarbazoles with aluminum isopropoxide", IZVESTIYA TOMSKOGO POLITEKHNICHESKOGO INSTITUTA , 126, 67-9 CODEN: ITPKAM; ISSN: 0368-0487, 1964, XP008058168
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