Title:
CARBOSTYRIL DERIVATIVES AND MOOD STABILIZERS FOR TREATING MOOD DISORDERS
Document Type and Number:
WIPO Patent Application WO2004105682
Kind Code:
A3
Abstract:
The pharmaceutical composition of the present invention comprises a carbostyril derivative which is a dopamine-serotonin system stabilizer and a mood stabilizer in a pharmaceutically acceptable carrier. The carbostyril derivative may be aripiprazole or a metabolite thereof. The mood stabilizer may include but is not limited to lithium, valproic acid, divalproex sodium, carbamazapine, oxcarbamazapine, zonisamide, lamotragine, topiramate, gabapentin, levetiracetam or clonazepam. These compositions are used to treat patients with mood disorders, particularly bipolar disorder with or without psychotic features, mania or mixed episodes. Methods are provided for separate administration of a carbostyril derivative and a mood stabilizer to a patient with a mood disorder.
Inventors:
KIKUCHI TETSURO (JP)
IWAMOTO TARO (US)
HIROSE TSUYOSHI (JP)
IWAMOTO TARO (US)
HIROSE TSUYOSHI (JP)
Application Number:
PCT/US2004/013308
Publication Date:
May 12, 2005
Filing Date:
May 19, 2004
Export Citation:
Assignee:
OTSUKA PHARMA CO LTD (JP)
KIKUCHI TETSURO (JP)
IWAMOTO TARO (US)
HIROSE TSUYOSHI (JP)
KIKUCHI TETSURO (JP)
IWAMOTO TARO (US)
HIROSE TSUYOSHI (JP)
International Classes:
A61K31/19; A61K31/47; A61K31/497; A61K31/519; A61K33/14; A61K45/06; A61K; (IPC1-7): A61K31/47; A61K31/19; A61K31/519
Domestic Patent References:
| WO2002087590A1 | 2002-11-07 | |||
| WO2003066039A1 | 2003-08-14 | |||
| WO2000059489A2 | 2000-10-12 | |||
| WO1999062522A1 | 1999-12-09 | |||
| WO1997035584A1 | 1997-10-02 |
Foreign References:
| US20030109546A1 | 2003-06-12 |
Other References:
GORDON A. ET AL.: "Mood stabilization and weight loss with topiramate", AMERICAN JOURNAL OF PSYCHIATRY, vol. 156, no. 6, June 1999 (1999-06-01), pages 968 - 969, XP000923382
BALDESSARINI ET AL.: "Hospital use of antipsychotic agents in 1989 and 1993: Stable dosing with decreased length of stay", AMERICAN JOURNAL OF PSYCHIATRY, vol. 152, no. 7, June 1995 (1995-06-01), pages 1038 - 1044, XP008016702
BALDESSARINI ET AL.: "Hospital use of antipsychotic agents in 1989 and 1993: Stable dosing with decreased length of stay", AMERICAN JOURNAL OF PSYCHIATRY, vol. 152, no. 7, June 1995 (1995-06-01), pages 1038 - 1044, XP008016702
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