Title:
CARBOXYLIC ACID COMPOUND, METHOD FOR PREPARING SAME, AND USE THEREOF IN PHARMACEUTICS
Document Type and Number:
WIPO Patent Application WO/2023/155873
Kind Code:
A1
Abstract:
The present application provides a carboxylic acid compound, a method for preparing same, and use thereof in pharmaceutics. Specifically, the present application provides a carboxylic acid compound represented by formula (I), a method for preparing same, a pharmaceutical composition comprising the compound, and use thereof as a therapeutic, in particular, use thereof as a soluble guanylate cyclase (sGC) agonist and/or activator and use thereof in preparing a medicament for treating and/or preventing a disease or condition mediated by sGC.
Inventors:
FAN XING (CN)
CHEN YUAN (CN)
WU XIAO (CN)
YAN JINGJING (CN)
HE FENG (CN)
TAO WEIKANG (CN)
CHEN YUAN (CN)
WU XIAO (CN)
YAN JINGJING (CN)
HE FENG (CN)
TAO WEIKANG (CN)
Application Number:
PCT/CN2023/076748
Publication Date:
August 24, 2023
Filing Date:
February 17, 2023
Export Citation:
Assignee:
JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C233/55; A61K31/196; A61P9/00
Domestic Patent References:
| WO2020245342A1 | 2020-12-10 |
Foreign References:
| CN102712577A | 2012-10-03 | |||
| CN103492361A | 2014-01-01 | |||
| CN103796989A | 2014-05-14 | |||
| CN104470895A | 2015-03-25 |
Other References:
HAHN, M. G. ET AL.: "Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042", JOURNAL OF MEDICINAL CHEMISTRY, vol. 64, no. 9, 19 April 2021 (2021-04-19), pages 5323 - 5344, XP055875547, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.0c02154
DATABASE REGISTRY 2 November 2017 (2017-11-02), ANONYMOUS : " [1,1'-Biphenyl]-2-carboxylic acid, 3'-amino-5'-chloro- (CA INDEX NAME) OTHER CA INDEX NAMES", XP093086384, retrieved from STN Database accession no. 2138102-94-8
DATABASE REGISTRY 2 November 2017 (2017-11-02), ANONYMOUS : " [1,1'-Biphenyl]-2-carboxylic acid, 3'-amino-5'-chloro- (CA INDEX NAME) OTHER CA INDEX NAMES", XP093086384, retrieved from STN Database accession no. 2138102-94-8
Attorney, Agent or Firm:
GE CHENG & CO., LTD et al. (CN)
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