Title:
CARBOXYLIC ACID DERIVATIVE COMPOUNDS AND DRUGS COMPRISING THESE COMPOUNDS AS THE ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2003/016254
Kind Code:
A1
Abstract:
Carboxylic acid derivatives represented by the following general formula (I) and nontoxic salts thereof: (I) wherein R1 represents COOH, COOR4 (wherein R4 represents alkyl, etc.), etc.&semi A represents alkylene, etc.&semi R2 represents alkyl, etc.&semi m is 0, etc.&semi B represents a benzene ring, etc.&semi Q represents an alkylene−Cyc 2 (wherein Cyc 2 represents a heterocycle, etc.), an alkylene−o−benzene ring, etc.&semi D represents O−alkylene, NHCO−alkylene, etc.&semi and R3 represents a benzene ring, a naphthalene ring, etc. Because of binding to PEG2 receptors, in particular, subtype EP3 and&sol or subtype EP4 and having antagonism, the compounds represented by the general formula (I) are useful in preventing and&sol or treating diseases such as pain.
Inventors:
TANI KOUSUKE (JP)
ASADA MASAKI (JP)
KOBAYASHI KAORU (JP)
NARITA MASAMI (JP)
OGAWA MIKIO (JP)
ASADA MASAKI (JP)
KOBAYASHI KAORU (JP)
NARITA MASAMI (JP)
OGAWA MIKIO (JP)
Application Number:
PCT/JP2002/008120
Publication Date:
February 27, 2003
Filing Date:
August 08, 2002
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
TANI KOUSUKE (JP)
ASADA MASAKI (JP)
KOBAYASHI KAORU (JP)
NARITA MASAMI (JP)
OGAWA MIKIO (JP)
TANI KOUSUKE (JP)
ASADA MASAKI (JP)
KOBAYASHI KAORU (JP)
NARITA MASAMI (JP)
OGAWA MIKIO (JP)
International Classes:
C07C57/44; C07C59/68; C07C69/734; C07C69/736; C07C69/738; C07C229/34; C07C309/66; C07C309/67; C07C309/73; C07C311/06; C07C311/08; C07C311/19; C07C311/29; C07C311/51; C07C317/18; C07C317/22; C07C317/40; C07C317/50; C07C323/19; C07C323/42; C07C323/59; C07C323/60; C07D521/00; C07C57/40; (IPC1-7): C07C57/40; C07C57/44; C07C69/736; C07C229/34; C07C233/47; C07C233/55; C07C233/65; C07C233/81; C07C233/87; C07C235/38; C07C235/42; C07C235/46; C07C235/48; C07C235/54; C07C235/56; C07C237/30; C07C239/18; C07C255/37; C07C255/55; C07C255/57; C07C255/58; C07C255/60; C07C271/22; C07C271/28; C07C271/58; C07C275/42; C07C309/65; C07C309/73; C07C311/06; C07C311/08; C07C311/13; C07C311/17; C07C311/21; C07C311/29; C07C317/14; C07C317/22; C07C317/32; C07C317/46; C07C317/48; C07C321/20; C07C321/28; C07D207/38; C07D207/325; C07D209/08; C07D209/42; C07D211/44; C07D211/58; C07D211/96; C07D213/30; C07D213/64; C07D213/65; C07D213/74; C07D215/12; C07D215/48; C07D231/12; C07D233/84; C07D235/08; C07D241/18; C07D249/08; C07D257/06; C07D261/10; C07D265/30; C07D277/36; C07D277/66; C07D277/68; C07D295/08; C07D295/18; C07D307/85; C07D309/08; C07D317/64; C07D333/20; C07D333/24; C07D333/60; C07D335/02; C07D401/12; C07D403/12; C07D405/12; C07D409/06; C07D409/12; C07D413/12; C07D417/10; C07D417/12; A61K31/192; A61K31/216; A61K31/343; A61K31/351; A61K31/36; A61K31/381; A61K31/382; A61K31/40; A61K31/4015; A61K31/404; A61K31/41; A61K31/415; A61K31/4155; A61K31/4164; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/42; A61K31/4245; A61K31/426; A61K31/427; A61K31/433; A61K31/435; A61K31/44; A61K31/445; A61K31/4468; A61K31/451; A61K31/47; A61K31/473; A61K31/4725; A61K31/495; A61K31/4965; A61K31/5375; A61K31/538; A61P1/00; A61P1/02; A61P1/04; A61P1/10; A61P1/16; A61P5/24; A61P7/02; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P13/00; A61P13/12; A61P17/00; A61P17/02; A61P19/00; A61P19/02; A61P19/10; A61P25/00; A61P25/04; A61P25/18; A61P25/20; A61P25/22; A61P25/28; A61P27/02; A61P29/00; A61P31/18; A61P35/00; A61P37/00; A61P37/02; A61P37/08; A61P43/00
Domestic Patent References:
WO2002016311A1 | 2002-02-28 | |||
WO1996010569A1 | 1996-04-11 | |||
WO2000003980A1 | 2000-01-27 | |||
WO2001049661A1 | 2001-07-12 | |||
WO2000015608A1 | 2000-03-23 |
Foreign References:
EP0985663A1 | 2000-03-15 |
Other References:
See also references of EP 1431267A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Horiguchi No.2 Bldg. 7F 2-6,
Nihonbashi-Ningyocho, 2-chom, Chuo-ku Tokyo, JP)
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