Title:
CARBOXYLIC ACID DERIVATIVE AND SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2002/100812
Kind Code:
A1
Abstract:
A medicine containing as the active ingredient a novel carboxylic acid derivative useful as an insulin resistance ameliorant. The carboxylic acid derivative is represented by the following general formula (I). Also provided are a salt or ester of the derivative and a hydrate of either. (I) In the formula, R1 represents carboxyl, alkyl, alkoxy, etc.&semi L and T each represents a single bond, alkylene, alkynylene, etc.&semi M represents alkylene, etc.&semi W represents carboxyl&semi X represents oxygen, −NRX1CQ1O−, −OCQ1NRX1−, −CQ1NRX1O− (wherein Q1 represents oxygen, etc. and RX1 represents hydrogen, alkyl, etc.), etc.&semi and Y and Z each represents an optionally substituted 5− to 14−membered aromatic group, etc.
Inventors:
MATSUURA FUMIYOSHI (JP)
EMORI EITA (JP)
SHINODA MASANOBU (JP)
CLARK RICHARD (JP)
KASAI SHUNJI (JP)
YOSHITOMI HIDEKI (JP)
YAMAZAKI KAZUTO (JP)
INOUE TAKASHI (JP)
MIYASHITA SADAKAZU (JP)
HIHARA TARO (JP)
HARADA HITOSHI (JP)
OHASHI KAYA (JP)
EMORI EITA (JP)
SHINODA MASANOBU (JP)
CLARK RICHARD (JP)
KASAI SHUNJI (JP)
YOSHITOMI HIDEKI (JP)
YAMAZAKI KAZUTO (JP)
INOUE TAKASHI (JP)
MIYASHITA SADAKAZU (JP)
HIHARA TARO (JP)
HARADA HITOSHI (JP)
OHASHI KAYA (JP)
Application Number:
PCT/JP2002/003866
Publication Date:
December 19, 2002
Filing Date:
April 18, 2002
Export Citation:
Assignee:
EISAI CO LTD (JP)
MATSUURA FUMIYOSHI (JP)
EMORI EITA (JP)
SHINODA MASANOBU (JP)
CLARK RICHARD (JP)
KASAI SHUNJI (JP)
YOSHITOMI HIDEKI (JP)
YAMAZAKI KAZUTO (JP)
INOUE TAKASHI (JP)
MIYASHITA SADAKAZU (JP)
HIHARA TARO (JP)
HARADA HITOSHI (JP)
OHASHI KAYA (JP)
MATSUURA FUMIYOSHI (JP)
EMORI EITA (JP)
SHINODA MASANOBU (JP)
CLARK RICHARD (JP)
KASAI SHUNJI (JP)
YOSHITOMI HIDEKI (JP)
YAMAZAKI KAZUTO (JP)
INOUE TAKASHI (JP)
MIYASHITA SADAKAZU (JP)
HIHARA TARO (JP)
HARADA HITOSHI (JP)
OHASHI KAYA (JP)
International Classes:
A61P1/00; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P19/10; A61P25/28; A61P29/00; A61P35/00; A61P37/02; C07C59/58; C07C59/68; C07C59/72; C07C233/25; C07C235/24; C07C251/48; C07C251/52; C07C251/54; C07C255/37; C07C255/54; C07C259/10; C07C271/14; C07C271/16; C07C271/22; C07C271/28; C07C271/58; C07C309/73; C07C309/75; C07C311/19; C07C317/18; C07C317/22; C07C323/20; C07D209/08; C07D209/18; C07D209/24; C07D213/30; C07D213/65; C07D213/68; C07D213/73; C07D213/75; C07D215/14; C07D215/18; C07D215/26; C07D235/06; C07D235/12; C07D277/56; C07C59/64; C07D295/096; C07D295/192; C07D307/79; C07D317/54; C07D413/12; C07D417/12; (IPC1-7): C07C59/64; C07C59/66; C07C59/68; C07C59/72; C07C59/90; C07C233/25; C07C251/50; C07C251/52; C07C251/54; C07C255/54; C07C271/22; C07C271/28; C07C271/58; C07C309/73; C07C309/75; C07C311/17; C07C317/22; C07D213/64; C07D213/65; C07D215/20; C07D215/22; C07D295/18; C07D317/72; C07D333/16; C07D417/04; A61K31/192; A61K31/27; A61K31/357; A61K31/381; A61K31/40; A61K31/425; A61K31/427; A61K31/44; A61K31/47; A61K31/4704; A61P1/00; A61P1/04; A61P1/18; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P19/10; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P43/00
Domestic Patent References:
| WO1999018066A1 | 1999-04-15 | |||
| WO1989003819A1 | 1989-05-05 | |||
| WO1994013650A1 | 1994-06-23 | |||
| WO1994001420A1 | 1994-01-20 | |||
| WO1995003288A1 | 1995-02-02 | |||
| WO1990006920A1 | 1990-06-28 | |||
| WO2001055086A1 | 2001-08-02 | |||
| WO2001055085A1 | 2001-08-02 |
Foreign References:
| JPS5764639A | 1982-04-19 | |||
| DE3026924A1 | 1982-02-18 | |||
| EP0543662A2 | 1993-05-26 | |||
| EP0219308A2 | 1987-04-22 | |||
| JP2001261612A | 2001-09-26 |
Other References:
YOUNG PAUL W. ET AL.: "Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 284, no. 2, 1997, pages 751 - 759, XP002954133
HAIGH DAVID ET AL.: "Non-thiazolidinedione antihyperglycaemic agents. Part 3: The effects of stereochemistry on the potency of alpha-methoxy-beta-phenylpropanoic acids", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, no. 5, 1999, pages 821 - 830, XP000995637
"Nuovi coloranti per miste poliestere/cotone", TINCTORIA, vol. 93, no. 5, 1996, pages 34 - 39, XP002954134
GIBSON D. ET AL.: "Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 10, 1997, pages 823 - 831, XP004172153
LAVOIE RICO ET AL.: "Design and synthesis of a novel class of histone deacetylase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 21, 2001, pages 2847 - 2850, XP002954135
See also references of EP 1380562A4
HAIGH DAVID ET AL.: "Non-thiazolidinedione antihyperglycaemic agents. Part 3: The effects of stereochemistry on the potency of alpha-methoxy-beta-phenylpropanoic acids", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 7, no. 5, 1999, pages 821 - 830, XP000995637
"Nuovi coloranti per miste poliestere/cotone", TINCTORIA, vol. 93, no. 5, 1996, pages 34 - 39, XP002954134
GIBSON D. ET AL.: "Anthraquinone intercalators as carrier molecules for second-generation platinum anticancer drugs", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 32, no. 10, 1997, pages 823 - 831, XP004172153
LAVOIE RICO ET AL.: "Design and synthesis of a novel class of histone deacetylase inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 21, 2001, pages 2847 - 2850, XP002954135
See also references of EP 1380562A4
Attorney, Agent or Firm:
Furuya, Kaoru (6th Floor 2-17-8, Nihonbashi-Hamach, Chuo-ku Tokyo, JP)
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