Title:
CARCINOSTATIC AGENT, CARCINOGENESIS INHIBITOR AND LIFE-PROLONGING AGENT, COMPRISING NOVEL COMPOUND WITH MTORC1 INHIBITORY EFFECT
Document Type and Number:
WIPO Patent Application WO/2022/065424
Kind Code:
A1
Abstract:
A carcinostatic agent, a carcinogenesis inhibitor and/or a life-prolonging agent each comprising a compound with mTORC1 inhibitory effect, said compound having partial structures (I), (II) and (III), or a pharmacologically acceptable salt thereof. (In the formulae: R1, R2, R3 and R4 are the same or different and represent an H, a lower alkyl, a lower haloalkyl, a lower alkoxy, a lower alkylamino, an OH, a protected OH, an amino, a protected amino, a carboxy, a protected carboxy or a halogen atom; R5 and R6 are the same or different and represent an H or a protecting group of an OH, or R5 and R6 form together a methylene or dimethylmethylene group; and A represents O or S.)
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Inventors:
MIYATAKE HIDEYUKI (JP)
ITO YOSHIHIRO (JP)
SHAMS RAEF SOLIMAN AHMED (JP)
MATSUKAWA AKIHIRO (JP)
ITO YOSHIHIRO (JP)
SHAMS RAEF SOLIMAN AHMED (JP)
MATSUKAWA AKIHIRO (JP)
Application Number:
PCT/JP2021/035038
Publication Date:
March 31, 2022
Filing Date:
September 24, 2021
Export Citation:
Assignee:
RIKEN (JP)
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
NAT UNIV CORPORATION OKAYAMA UNIV (JP)
International Classes:
A61K31/517; A61P35/00; A61P43/00
Domestic Patent References:
| WO2009023558A1 | 2009-02-19 |
Foreign References:
| JP2020519567A | 2020-07-02 | |||
| JP2011507910A | 2011-03-10 |
Other References:
DATABASE REGISTRY [Online]. US: American Chemical Society [retrieved on 18 October 2021], Retrieved from STN., registry no. 2097920-80-2, 899937-70-3, 899937-50-9, 899937-47-4, 899937-44-1, 899937-41-8, 899937-38-3, 899937-35-0, 899922-42-0, 899922-39-5, 899916-36-0, 899910-80-6, 899910-53-3, 899910-50-0, 899910-47-5, 899910-41-9, 899910-39-5, 899787-90-7, 899921-47-2, 899907-54-1, 892267-23-1
URSULA D. RAMIREZ;ANNA S. NIKONOVA;HANQING LIU;ANNA PECHERSKAYA;SARAH H. LAWRENCE;ILYA G. SEREBRIISKII;YAN ZHOU;MATTHEW K. ROBINSO: "Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 15, no. 1, 28 May 2015 (2015-05-28), LONDON, GB , pages 436, XP021223833, ISSN: 1471-2407, DOI: 10.1186/s12885-015-1415-6
MUTHUKUMAR VIJEY AANANDHI, BHATTACHERJEE DEBOJIT, VIJEY AANANDHI M, SRI RAMYA T, SUJATHA R: "SYNTHESIS,CHARACTERIZATION, ANTI-PROSTATE CANCER DOCKING AND IDENTIFICATION OF TARGET SITE OF VARIOUS MANNICH BASES OF QUINAZOLINONES", 1 January 2013 (2013-01-01), XP055915709, Retrieved from the Internet [retrieved on 20220426]
C. L. DOMINGUEZ, FLOYD D. H., XIAO A., MULLINS G. R., KEFAS B. A., XIN W., YACUR M. N., ABOUNADER R., LEE J. K., WILSON G. M., HAR: "Diacylglycerol Kinase alpha is a Critical Signaling Node and Novel Therapeutic Target in Glioblastoma and Other Cancers", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 3, no. 7, 1 July 2013 (2013-07-01), US , pages 782 - 797, XP055611381, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-12-0215
HARA, KENTA: "Roles of mTOR in ageing and longevity", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 74, no. 9, 1 January 2016 (2016-01-01), JP , pages 1479 - 1484, XP009535210, ISSN: 0047-1852
URSULA D. RAMIREZ;ANNA S. NIKONOVA;HANQING LIU;ANNA PECHERSKAYA;SARAH H. LAWRENCE;ILYA G. SEREBRIISKII;YAN ZHOU;MATTHEW K. ROBINSO: "Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization", BMC CANCER, BIOMED CENTRAL, LONDON, GB, vol. 15, no. 1, 28 May 2015 (2015-05-28), LONDON, GB , pages 436, XP021223833, ISSN: 1471-2407, DOI: 10.1186/s12885-015-1415-6
MUTHUKUMAR VIJEY AANANDHI, BHATTACHERJEE DEBOJIT, VIJEY AANANDHI M, SRI RAMYA T, SUJATHA R: "SYNTHESIS,CHARACTERIZATION, ANTI-PROSTATE CANCER DOCKING AND IDENTIFICATION OF TARGET SITE OF VARIOUS MANNICH BASES OF QUINAZOLINONES", 1 January 2013 (2013-01-01), XP055915709, Retrieved from the Internet
C. L. DOMINGUEZ, FLOYD D. H., XIAO A., MULLINS G. R., KEFAS B. A., XIN W., YACUR M. N., ABOUNADER R., LEE J. K., WILSON G. M., HAR: "Diacylglycerol Kinase alpha is a Critical Signaling Node and Novel Therapeutic Target in Glioblastoma and Other Cancers", CANCER DISCOVERY, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 3, no. 7, 1 July 2013 (2013-07-01), US , pages 782 - 797, XP055611381, ISSN: 2159-8274, DOI: 10.1158/2159-8290.CD-12-0215
HARA, KENTA: "Roles of mTOR in ageing and longevity", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 74, no. 9, 1 January 2016 (2016-01-01), JP , pages 1479 - 1484, XP009535210, ISSN: 0047-1852
Attorney, Agent or Firm:
SIKS & CO. (JP)
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