Title:
CARCINOSTATIC AGENTS
Document Type and Number:
WIPO Patent Application WO/1999/010001
Kind Code:
A1
Abstract:
Agents capable of inhibiting the proliferation of cancer cells and cancers in the tissues therearound or unaffected tissues. Specifically, carcinostatic agents containing as the active ingredient mannan-binding proteins or genes thereof. The mannan-binding proteins include a protein having the amino acid sequence represented by SEQ ID NO:1 in the Sequence Listing and proteins having amino acid sequences derived therefrom by at least one of substitution, deletion, addition and insertion of one or more amino acids and having the activity as a mannan-binding protein. The above genes are exemplified by those encoding the amino acid sequences represented by SEQ ID NO:1 or 2 in the Sequence Listing, those encoding amino acid sequences derived therefrom by modification, and genes containing these genes.
Inventors:
KAWASAKI TOSHISUKE (JP)
Application Number:
PCT/JP1998/003697
Publication Date:
March 04, 1999
Filing Date:
August 19, 1998
Export Citation:
Assignee:
TAKARA SHUZO CO (JP)
KAWASAKI TOSHISUKE (JP)
KAWASAKI TOSHISUKE (JP)
International Classes:
A61K35/76; A61K38/17; C07H21/04; C07K14/435; C07K14/47; C12N5/06; C12N15/12; C12P21/02; A61K48/00; (IPC1-7): A61K35/76; A61K38/02; A61K48/00; C07K14/47; C12N15/12
Foreign References:
| JPS62205034A | 1987-09-09 | |||
| US5270199A | 1993-12-14 | |||
| JPH02504581A | 1990-12-27 | |||
| JPH073902T | ||||
| JPH06501620A | 1994-02-24 |
Other References:
FUJITA T. et al., "Mannose-Binding Protein Recognizes Glioma Cells: In Vitro Analysis of Complement Activation on Glioma Cells Via the Lectin Pathway", JPN. J. CANCER RES., 86, 1995, pp. 187-192.
SASTRY K. et al., "The Human Mannose-Binding Protein Gene", J. EXP. MED., 170, 1989, pp. 1175-1189.
KUNIO YAGI, "Cationic Liposomes (in Japanese)", "Gene Therapy (in Japanese)", PROTEIN, NUCLEIC ACID AND ENZYME, Special Extra Issue, Vol. 40, No. 17, 1995, pp. 2577-2582.
MOLECULAR BIOLOGY OF CELLS, 2nd Ed., (in Japanese), Supervised by KEIKO NAKAMURA, KENICHI MATSUBARA, KYOIKUSHA, 1990, pp. 1031-1036.
SASTRY K. et al., "The Human Mannose-Binding Protein Gene", J. EXP. MED., 170, 1989, pp. 1175-1189.
KUNIO YAGI, "Cationic Liposomes (in Japanese)", "Gene Therapy (in Japanese)", PROTEIN, NUCLEIC ACID AND ENZYME, Special Extra Issue, Vol. 40, No. 17, 1995, pp. 2577-2582.
MOLECULAR BIOLOGY OF CELLS, 2nd Ed., (in Japanese), Supervised by KEIKO NAKAMURA, KENICHI MATSUBARA, KYOIKUSHA, 1990, pp. 1031-1036.
Attorney, Agent or Firm:
Adati, Mituo (6th floor 6-20, Tosabori 1-chome Nishi-ku Osaka-shi Osaka, JP)
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