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Patent Searching and Data


Title:
CARDIOACTIVE COMPOSITION COMPRISING L-CARNITINE AND ITS DERIVATIVES AND CRATAEGUS EXTRACTS
Document Type and Number:
WIPO Patent Application WO/2001/003683
Kind Code:
A2
Abstract:
A composition is disclosed suitable for the prevention and/or therapeutic treatment of various disorders and pathological conditions of the cardiovascular system and which, therefore, may take the form of a dietary supplement, a dietetic support or an actual medicine, which comprises as its characterising active ingredients L-carnitine or proprionyl L-carnitine and a plant extract of the genus Crataegus (hawthorn).

Inventors:
CAVAZZA CLAUDIO (IT)
Application Number:
PCT/IT2000/000273
Publication Date:
January 18, 2001
Filing Date:
July 03, 2000
Export Citation:
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Assignee:
SIGMA TAU HEALTHSCIENCE SPA (IT)
CAVAZZA CLAUDIO (IT)
International Classes:
A61K31/00; A61K36/00; A61K36/734; A61K36/81; A61P9/00; A61K; (IPC1-7): A61K31/00
Foreign References:
US5948443A1999-09-07
US5976568A1999-11-02
Other References:
B.S.KENDLER: "Recent nutritional approaches to the prevention and therapy of cardiovascular disease" PROGRESS IN CARDIOVASCULAR NURSING, vol. 12, no. 3, 1997, pages 3-23, XP000978849
Attorney, Agent or Firm:
Cavattoni, Fabio (Viale dei Parioli 160, Roma, IT)
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Claims:
Claims
1. A combination composition which comprises: (a) a"carnitine"selected from the group comprising Lcarnitine and propionyl Lcarnitine or their pharmacologically acceptable salts or mixtures thereof ; (b) an extract of Crataegus.
2. The composition of claim 1, wherein the ingredient (a) further comprises a"carnitine"selected from the group comprising acetyl L carnitine, valeryl Lcarnitine, isovaleryl Lcarnitine and butyryl L carnitine or their pharmacologically acceptable salts or mixtures thereof.
3. The composition of claim 1 or 2, wherein the extract of Crataegus is an extract of berries, flowers, sprouts, leaves or mixture therof of plants belonging to Crataegus oxycantha, Crataegus monogyna, Crataegus levigata, Crataegus pinnatifida and Crataegus sinaica species.
4. The composition of claim 3, wherein the extracts of Crataegus comprise liquid, alcoholic, hydroalcoholic extracts, tinctures, nebulized extracts or dry powders of said Crataegus species.
5. The composition of claim 3 or 4, wherein said Crataegus extracts contain at least 2,2% by weight of flavonoids or 18.75% by weight of oligomeric procianides or 1% by weight of vitexine2rhamnoside.
6. The composition of any of the preceding claims wherein the pharmacologically acceptable salt of Lcarnitine or alkanoyl Lcarnitine is selected from the group comprising: chloride; bromide; iodide; aspartate, acid aspartate; citrate, acid citrate; tartrate; phosphate, acid phosphate; fumarate, acid fumarate; glycerophosphate; glucose phosphate; lactate; maleate, acid maleate; orotate; oxalate; acid oxalate; sulphate, acid sulphate; trichloroacetate; trifluoroacetate and methane sulphonate.
7. The composition of any of the preceding claims, which further comprises vitamins, coenzymes, mineral substances, aminoacids, and antioxidants.
8. The composition of any of the preceding claims, orally administrable, in the form of a dietary supplement.
9. The composition of any of claims 1 to 7, orally, parenterally, rectally, sublingually or transdermally administrable, in the form of a medicament.
10. The dietary supplement of claim 8, for the prevention of cardiovascular disorders, myocardial insufficiency, coronary disorders, vascular peripheral disorders, fatigue, cardiac arrythmias and erethism.
11. The medicament of claim 9, for the therapeutic treatment of cardiovascular disorders, myocardial insufficiency, coronary disorders, vascular peripheral disorders, fatigue, cardiac arrythmias and erethism.
12. The dietary supplement of claim 10, in solid, semiliquid or liquid form.
13. The medicament of claim 11, in solid, semiliquid or liquid form.
14. The dietary supplement of claim 12, in the form of tablets, lozenges, pills, capsules, granulates or syrups.
15. The medicament of claim 13, in the form of tables, lozenges, pills, capsules, granulates, syrups, vials or drops.
Description:
INTERNATIONAL SEARCH REPORT Int. tional Application No Information on patent family members PCT/I T 00/00273 PCT/IT 00/00273 Patent document Publication Patent family Publication cited in search report date member (s) date US 5948443 A 07-09-1999 US 5925348 A 20-07-1999 US 5976568 A 02-11-1999 NONE