Title:
CARDIOMYOCYTE PROPAGATION PROMOTING AGENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/156216
Kind Code:
A1
Abstract:
By using a drug that activates the cell cycle, such as a retinoic acid receptor agonist, a phosphatidylinositol 3-kinase (PI3K) inhibiting agent, or an isocitrate dehydrogenase 1 (IDH1) inhibiting agent, cardiomyocytes can be made to propagate efficiently, and engraftment rate at the time of transplantation can be increased.
Inventors:
YOSHIDA YOSHINORI (JP)
HATANI TAKESHI (JP)
KASAMOTO MANABU (JP)
FUNAKOSHI SHUNSUKE (JP)
HATANI TAKESHI (JP)
KASAMOTO MANABU (JP)
FUNAKOSHI SHUNSUKE (JP)
Application Number:
PCT/JP2019/004631
Publication Date:
August 15, 2019
Filing Date:
February 08, 2019
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C12N5/077; C12Q1/02; G01N33/15; G01N33/50; C12N5/0735; C12N5/10
Domestic Patent References:
| WO2015045333A1 | 2015-04-02 | |||
| WO2008114544A1 | 2008-09-25 |
Other References:
KIKUCHI K. ET AL.: "Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration", DEV. CELL, vol. 20, no. 3, 15 March 2011 (2011-03-15), pages 397 - 404, XP028167456, doi:10.1016/j.devcel.2011.01.010
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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