Title:
CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST BETA-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE
Document Type and Number:
WIPO Patent Application WO2006060122
Kind Code:
A9
Abstract:
The present invention provides compounds possessing inhibitory activity against ß adrenergic receptors and phosphodiesterase (PDE), including type 3 phosphodiesterase (PDE-3). The present invention further provides pharmaceutical compositions comprising such compounds, methods of preparing such compounds, and methods of using such compounds for regulating calcium homeostasis, for treating a disease, disorder or condition in which disregulation of calcium homeostasis is implicated and for treating cardiovascular disease, stroke, epilepsy, an ophthalmic disorder or migraine.
Inventors:
TAYLOR MALCOLM GEORGE (GB)
KLENKE BURKHARD (GB)
SUZDAK PETER D (US)
MAZHARI REZA (US)
KLENKE BURKHARD (GB)
SUZDAK PETER D (US)
MAZHARI REZA (US)
Application Number:
PCT/US2005/040409
Publication Date:
August 17, 2006
Filing Date:
November 08, 2005
Export Citation:
Assignee:
ARTESIAN THERAPEUTICS INC (US)
TAYLOR MALCOLM GEORGE (GB)
KLENKE BURKHARD (GB)
SUZDAK PETER D (US)
MAZHARI REZA (US)
TAYLOR MALCOLM GEORGE (GB)
KLENKE BURKHARD (GB)
SUZDAK PETER D (US)
MAZHARI REZA (US)
International Classes:
A61K31/495; A61P9/00; C07D237/04; C07D237/24; C07D401/04; C07D401/12; C07D401/14; C07D403/12
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