Title:
CARIES RISK TEST FOR PREDICTING AND ASSESSING THE RISK OF DISEASE
Document Type and Number:
WIPO Patent Application WO2004089187
Kind Code:
A3
Abstract:
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The method comprises providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of said saliva with one or more lectins under conditions that allow said one or more lectins to bind to a lectin-binding component of said saliva; detecting the amount of bound lectin; and comparing the amount of bound lectin to the amount known to bind a saliva sample from a control patient, to predict the risk of a disease in the subject. Also provided are methods for reducing the risk of a disease and a method for assessing the risk of the disease at a defined level.
Inventors:
DENNY PATRICIA A (US)
DENNY PAUL C (US)
NAVAZESH MAHVASH (US)
DENNY PAUL C (US)
NAVAZESH MAHVASH (US)
Application Number:
PCT/US2004/010169
Publication Date:
March 24, 2005
Filing Date:
April 01, 2004
Export Citation:
Assignee:
UNIV SOUTHERN CALIFORNIA (US)
DENNY PATRICIA A (US)
DENNY PAUL C (US)
NAVAZESH MAHVASH (US)
DENNY PATRICIA A (US)
DENNY PAUL C (US)
NAVAZESH MAHVASH (US)
International Classes:
C12Q1/68; G01N33/00; G01N33/53; G01N33/558; G01N33/68; A61B; (IPC1-7): C12Q1/68; G01N33/00; G01N33/53; G01N33/558
Foreign References:
| US5585241A | 1996-12-17 | |||
| US6436721B1 | 2002-08-20 |
Other References:
STEINFELD ET AL.: "Labeled neoglycoproteins and human lectins as diagnostic and potential functional markers in salivary glands of patients with Sjogren's syndrome", THE JOURNAL OF RHEUMATHOLOGY, vol. 27, 2000, pages 1910 - 1916, XP008041790
BELICE ET AL.: "Evaluation of salivary sialic acid level and Cu-Zn superoxide dismutase activity in type 1 diabetes mellitus", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 3, November 2000 (2000-11-01), pages 219 - 225, XP008041789
ASTOR ET AL.: "Xerostomia: A prevalent condition in the elderly", ENT-EAR, NOSE & THROAT JOURNAL, July 1999 (1999-07-01), pages 476 - 479, XP008041796
NIELSEN ET AL.: "Differential expression of human high-molecular weight salivary mucin (MG1) and low-molecular weight salivary mucin (MG2)", JOURNAL OF DENTAL RESEARCH, vol. 75, no. 11, November 1996 (1996-11-01), pages 1820 - 1826, XP008041816
BELICE ET AL.: "Evaluation of salivary sialic acid level and Cu-Zn superoxide dismutase activity in type 1 diabetes mellitus", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 3, November 2000 (2000-11-01), pages 219 - 225, XP008041789
ASTOR ET AL.: "Xerostomia: A prevalent condition in the elderly", ENT-EAR, NOSE & THROAT JOURNAL, July 1999 (1999-07-01), pages 476 - 479, XP008041796
NIELSEN ET AL.: "Differential expression of human high-molecular weight salivary mucin (MG1) and low-molecular weight salivary mucin (MG2)", JOURNAL OF DENTAL RESEARCH, vol. 75, no. 11, November 1996 (1996-11-01), pages 1820 - 1826, XP008041816
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