CARRIER PEPTIDE FRAGMENT AND USE THEREOF

Title:

CARRIER PEPTIDE FRAGMENT AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/048050

Kind Code:

A1

Abstract:

According to the present disclosure, provided is a carrier peptide fragment having excellent cell membrane permeability. The disclosed carrier peptide fragment comprises an amino acid sequence represented by SEQ ID NO: 1, KKRTLRKSNRKKR, in which the twelfth lysine residue from the N-terminal side of the amino acid sequence is a D-isomer, and the remainder of the amino acid residues are L-isomers.

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Inventors:

BAILEYKOBAYASHI NAHOKO (JP)
YOSHIDA TETSUHIKO (JP)

Application Number:

PCT/JP2023/024103

Publication Date:

March 07, 2024

Filing Date:

June 29, 2023

Export Citation:

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Assignee:

TOAGOSEI CO LTD (JP)

International Classes:

C07K7/08; C07K1/113; C07K1/13; C07K19/00; C12N1/15; C12N1/19; C12N5/10; C12N15/11; C12N15/54; C12N15/87

Domestic Patent References:

WO2011013700A1

2011-02-03

Foreign References:

JP2022047613A

2022-03-25

Other References:

VAN DEN BRAND DIRK; VEELKEN CORNELIA; MASSUGER LEON; BROCK ROLAND: "Penetration in 3D tumor spheroids and explants: Adding a further dimension to the structure-activity relationship of cell-penetrating peptides", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 1860, no. 6, 14 March 2018 (2018-03-14), AMSTERDAM, NL , pages 1342 - 1349, XP085383441, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2018.03.007
NAJJAR KRISTINA, ERAZO-OLIVERAS ALFREDO, BROCK DAKOTA J., WANG TING-YI, PELLOIS JEAN-PHILIPPE: "An l- to d-Amino Acid Conversion in an Endosomolytic Analog of the Cell-penetrating Peptide TAT Influences Proteolytic Stability, Endocytic Uptake, and Endosomal Escape", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 292, no. 3, 1 January 2017 (2017-01-01), US , pages 847 - 861, XP093145576, ISSN: 0021-9258, DOI: 10.1074/jbc.M116.759837

Attorney, Agent or Firm:

ABE, Makoto (JP)

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