Title:
CARTILAGE EXTRACT WITH EFFECT OF IMPROVING IMMUNE RESPONSE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/199631
Kind Code:
A1
Abstract:
A cartilage extract with the effect of improving immune response, a preparation method therefor, and a use thereof. The cartilage extract uses animal cartilage as a raw material, and a cartilage extract containing undenatured type II collagen of an effective amount for improving immune response is obtained by means of adding sodium hyaluronate and lentinan at a mass ratio of 4:1 to 1:1, being capable of simultaneously preventing microbial spoilage of the cartilage extract and denaturation of the type II collagen during the storage period, and thereby improving the safety and storability of the product. The obtained cartilage extract has the advantages of high safety and effectiveness and has the effects of improving immune response, increasing the content of serum anti-inflammatory factors such as TGF-β, and reducing the content of inflammatory factors such as TNF-α, and can therefore be added to health food or functional food as a food raw material.
Inventors:
WANG HAIYAN (CN)
LIU AIQING (CN)
YAN ZHENG (CN)
LIU LIGE (CN)
LIU AIQING (CN)
YAN ZHENG (CN)
LIU LIGE (CN)
Application Number:
PCT/CN2022/082557
Publication Date:
September 29, 2022
Filing Date:
March 23, 2022
Export Citation:
Assignee:
BEIJING SEMNL BIOTECHNOLOGY CO LTD (CN)
International Classes:
C12P21/06; A23B4/20; A61K38/17; C08B37/08
Foreign References:
| CN106916870A | 2017-07-04 | |||
| CN110583756A | 2019-12-20 | |||
| JP2012176926A | 2012-09-13 | |||
| US5856446A | 1999-01-05 | |||
| US20150119335A1 | 2015-04-30 | |||
| US20160324146A1 | 2016-11-10 | |||
| CN106916870A | 2017-07-04 |
Other References:
LIU YINGMEI, ZHEN-AI LI, FEI LIU, XI-QIANG ZHU, PEI-XUE LING, YI-SHAN SU, HAI-JUN LI, XIU-HUA ZHANG: "Application of Edible Polysaccharide Compound Preservatives in Chilled Pork", SHIPIN YU YAOPIN = FOOD AND DRUG, SHANDONG SHENG SHENGWU YAOWU YANJIUYUAN, CHINA, vol. 20, no. 2, 20 March 2018 (2018-03-20), China , pages 114 - 117, XP055970892, ISSN: 1672-979X
WEI BAOYAO, YU XIAO-YING, HUANG LI, TENG JIAN-WEN : "Agaricus Bosporus (Lange) Sing Polysancchaeride Anti-Bacterial Reactive and to Curb Corruption in the Food Research", FOOD SCIENCE AND TECHNOLOGY, BEIJING SHI LIANGSHI KEXUE YANJIUSUO,, CN, no. 4, 20 April 2007 (2007-04-20), CN , pages 93 - 95, XP055970882, ISSN: 1005-9989, DOI: 10.13684/j.cnki.spkj.2007.04.029
BAO ZHIBI, CHEN RENWEI;LIU WANGJING;ZHAO YAXING;FAN ZEJUN;KHAS-ERDENE;AO CHANGJIN: "Research Progress of the Preservative Effect of Plant Extracts on Food and Its Mechanism", FEED INDUSTRY, vol. 39, no. 12, 25 June 2018 (2018-06-25), pages 58 - 64, XP055970887, ISSN: 1001-991X, DOI: 10.13302/j.cnki.fi.2018.12.011
WANG YAOHUA, JIADONG LIU, ZINUO WANG, JIE ZHUANG, YUPING TANG, TIANYI HUANG, YI ZHAO: "Comparison of Test Results of Antibacterial and Antiseptic Effects of Zinc Hyaluronate", QUALITY SAFETY INSPECTION AND TESTING, vol. 30, no. 6, 20 December 2020 (2020-12-20), XP055970877, ISSN: 2096-8876
WEI BAOYAO, YU XIAO-YING, HUANG LI, TENG JIAN-WEN : "Agaricus Bosporus (Lange) Sing Polysancchaeride Anti-Bacterial Reactive and to Curb Corruption in the Food Research", FOOD SCIENCE AND TECHNOLOGY, BEIJING SHI LIANGSHI KEXUE YANJIUSUO,, CN, no. 4, 20 April 2007 (2007-04-20), CN , pages 93 - 95, XP055970882, ISSN: 1005-9989, DOI: 10.13684/j.cnki.spkj.2007.04.029
BAO ZHIBI, CHEN RENWEI;LIU WANGJING;ZHAO YAXING;FAN ZEJUN;KHAS-ERDENE;AO CHANGJIN: "Research Progress of the Preservative Effect of Plant Extracts on Food and Its Mechanism", FEED INDUSTRY, vol. 39, no. 12, 25 June 2018 (2018-06-25), pages 58 - 64, XP055970887, ISSN: 1001-991X, DOI: 10.13302/j.cnki.fi.2018.12.011
WANG YAOHUA, JIADONG LIU, ZINUO WANG, JIE ZHUANG, YUPING TANG, TIANYI HUANG, YI ZHAO: "Comparison of Test Results of Antibacterial and Antiseptic Effects of Zinc Hyaluronate", QUALITY SAFETY INSPECTION AND TESTING, vol. 30, no. 6, 20 December 2020 (2020-12-20), XP055970877, ISSN: 2096-8876
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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