Title:
CARTILAGE REGENERATION USING COMBINATION OF IL-8 AND BONE MARROW CONCENTRATE
Document Type and Number:
WIPO Patent Application WO/2018/012736
Kind Code:
A1
Abstract:
The preset invention relates to cartilage regeneration using a combination of IL-8 and a bone marrow concentrate and, more specifically, provides: a composition for cartilage regeneration comprising IL-8 and a bone marrow concentrate as active ingredients; a filer for cartilage regeneration; a pharmaceutical composition for treating bone diseases or cartilage diseases; and a support for cartilage regeneration comprising IL-8 and a bone marrow concentrate, which are in a biodegradable support. The composition and support can be effectively used in the cartilage regeneration and the treatment of bone diseases or cartilage diseases.
Inventors:
LEE JIN WOO (KR)
YOON DONG SUK (KR)
KIM SUNG HWAN (KR)
YOON DONG SUK (KR)
KIM SUNG HWAN (KR)
Application Number:
PCT/KR2017/005620
Publication Date:
January 18, 2018
Filing Date:
May 30, 2017
Export Citation:
Assignee:
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIV (KR)
International Classes:
A61K38/20; A61K35/12; A61K35/28; A61L27/14; A61L27/36; A61L27/52; A61L27/54
Foreign References:
| JP2011523934A | 2011-08-25 | |||
| KR20120102501A | 2012-09-18 |
Other References:
CHOI ET AL.: "Synergistic Action of Interleukin-8 and Bone Marrow Concentrate on Cartilage Regeneration through Up-regulation of Chondrogenic Transcription Factors", ORTHOPAEDIC RESEARCH SOCIETY (ORS) 2016 ANNUAL MEETING, 5 March 2016 (2016-03-05), Orlando
CAVALLO ET AL.: "Chondrogenic Differentiation of Bone Marrow Concentrate Grown onto a Hylauronan Scaffold: Rationale for Its Use in the Treatment of Cartilage Lesions", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 101A, no. 6, 7 November 2012 (2012-11-07), pages 1559 - 1570, XP055459239
SAMPSON ET AL.: "Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-articular Orthobiologic for Cartilage Disease", THE PHYSICIAN AND SPORTSMEDICINE, vol. 41, no. 3, 2013, pages 7 - 18
YOON ET AL.: "Synergistic Action of IL-8 and Bone Marrow Concentrate on Cartilage Regeneration through Upregulation of Chondrogenic Transcription Factors", TISSUE ENGINEERING PART A, vol. 22, no. 3-4, 26 January 2016 (2016-01-26), pages 363 - 374, XP055459236
KIM ET AL.: "PO-104)Synergistic Action of IL -8 and BMC on Cartilage Regeneration through Up-regulation of Chondrogenic Transcription Factors", THE KOREAN SOCIETY FOR BIOMATERIALS (KSBM) 2016 SPRING CONFERENCE, THESIS, vol. 20, no. 1, 25 March 2016 (2016-03-25)
CHOI, SEONG MI ET AL.: "Synergistic Effect of IL -8 and BMC on Cartilage Regeneration through Up-regulation of Sox9", THE 5TH KOREAN SOCIETY OF STEM CELL AND REGENERATIVE MEDICINE FOR LOCOMOTOR SYSTEM CONFERENCE, SESSION 4. FREE COMMUNICATION II, 8 May 2016 (2016-05-08)
CAVALLO ET AL.: "Chondrogenic Differentiation of Bone Marrow Concentrate Grown onto a Hylauronan Scaffold: Rationale for Its Use in the Treatment of Cartilage Lesions", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, vol. 101A, no. 6, 7 November 2012 (2012-11-07), pages 1559 - 1570, XP055459239
SAMPSON ET AL.: "Autologous Bone Marrow Concentrate: Review and Application of a Novel Intra-articular Orthobiologic for Cartilage Disease", THE PHYSICIAN AND SPORTSMEDICINE, vol. 41, no. 3, 2013, pages 7 - 18
YOON ET AL.: "Synergistic Action of IL-8 and Bone Marrow Concentrate on Cartilage Regeneration through Upregulation of Chondrogenic Transcription Factors", TISSUE ENGINEERING PART A, vol. 22, no. 3-4, 26 January 2016 (2016-01-26), pages 363 - 374, XP055459236
KIM ET AL.: "PO-104)Synergistic Action of IL -8 and BMC on Cartilage Regeneration through Up-regulation of Chondrogenic Transcription Factors", THE KOREAN SOCIETY FOR BIOMATERIALS (KSBM) 2016 SPRING CONFERENCE, THESIS, vol. 20, no. 1, 25 March 2016 (2016-03-25)
CHOI, SEONG MI ET AL.: "Synergistic Effect of IL -8 and BMC on Cartilage Regeneration through Up-regulation of Sox9", THE 5TH KOREAN SOCIETY OF STEM CELL AND REGENERATIVE MEDICINE FOR LOCOMOTOR SYSTEM CONFERENCE, SESSION 4. FREE COMMUNICATION II, 8 May 2016 (2016-05-08)
Attorney, Agent or Firm:
HONESTY & JR PARTNERS INTELLECTUAL PROPERTY LAW GROUP (KR)
Download PDF:
Previous Patent: GUIDING APPARATUS FOR IMPLANT PROCEDURE
Next Patent: ELECTRONIC DEVICE AND ELECTRONIC DEVICE OPERATING METHOD
Next Patent: ELECTRONIC DEVICE AND ELECTRONIC DEVICE OPERATING METHOD