Title:
CASEIN HYDROLYSATE COMBINED WITH GINKGO BILOBA LEAF EXTRACT AND OPTIONALLY WHEY PROTEIN HYDROLYSATE
Document Type and Number:
WIPO Patent Application WO/2020/058553
Kind Code:
A3
Abstract:
The present invention relates to the field of food-type compositions. Specifically, it relates to a composition comprising at least one milk protein hydrolysate and a Ginkgo biloba extract. It also relates to the use of said composition for improving endothelial function, inter alia for treating erectile dysfunction and female sexual dysfunction.
Inventors:
GÓMEZ SALA BEATRIZ (ES)
GÓMEZ SALA ÁLVARO (ES)
LIU CHI-YU (ES)
GÓMEZ SALA ÁLVARO (ES)
LIU CHI-YU (ES)
Application Number:
PCT/ES2019/070623
Publication Date:
August 13, 2020
Filing Date:
September 20, 2019
Export Citation:
Assignee:
BIOPEPTIDE SL (ES)
International Classes:
A61K38/01; A23J3/34; A23L33/105; A61K36/16; A61P15/10
Foreign References:
| JP3805804B2 | 2006-08-09 | |||
| JPH06211690A | 1994-08-02 |
Other References:
ANONYMOUS: "Blood Pressure Health", 10 March 2018 (2018-03-10), pages 1 - 5, XP055667297, Retrieved from the Internet
ANONYMOUS: "Blood Pressure Health - Ingredients", 10 March 2018 (2018-03-10), pages 1 - 7, XP055667316, Retrieved from the Internet [retrieved on 20200211]
TOWNSEND R R ET AL: "A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension", AMERICAN JOURNAL OF HYPERTENSION, NATURE PUBLISHING GROUP, UNITED STATES, vol. 17, no. 11, 1 November 2004 (2004-11-01), pages 1056 - 1058, XP004632273, ISSN: 0895-7061, DOI: 10.1016/J.AMJHYPER.2004.06.018
HIDEAKI K ET AL: "Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. C. COMPARATIVEPHARMACOLOGY, PERGAMON PRESS , OXFORD, GB, vol. 96, no. 2, 1 January 1990 (1990-01-01), pages 367 - 371, XP025890577, ISSN: 0306-4492, [retrieved on 19900101], DOI: 10.1016/0742-8413(90)90023-3
MARIEKE H. SCHOEMAKER ET AL: "A casein hydrolysate based formulation attenuates obesity and associated non-alcoholic fatty liver disease and atherosclerosis in LDLr-/-.Leiden mice", PLOS ONE, vol. 12, no. 7, 5 July 2017 (2017-07-05), pages e0180648, XP055458592, DOI: 10.1371/journal.pone.0180648
TIM T. LAMBERS ET AL: "Clustering analyses in peptidomics revealed that peptide profiles of infant formulae are descriptive", FOOD SCIENCE & NUTRITION, vol. 3, no. 1, 30 December 2014 (2014-12-30), pages 81 - 90, XP055667844, ISSN: 2048-7177, DOI: 10.1002/fsn3.196
WANG BO ET AL: "The absorbates of positively charged peptides from casein show high inhibition ability of LDL oxidationin vitro: Identification of intact absorbed peptides", JOURNAL OF FUNCTIONAL FOODS, ELSEVIER BV, NL, vol. 20, 1 December 2015 (2015-12-01), pages 380 - 393, XP029360092, ISSN: 1756-4646, DOI: 10.1016/J.JFF.2015.11.012
JIAN MING WEI ET AL: "Experimental research Ginkgo suppresses atherosclerosis through downregulating the expression of connexin 43 in rabbits", ARCHIVES OF MEDICAL SCIENCE, vol. 2, 1 January 2013 (2013-01-01), pages 340 - 346, XP055667879, ISSN: 1734-1922, DOI: 10.5114/aoms.2013.34416
ALHAJ O A ET AL: "Hypocholesterolaemic effect of Bifidobacterium animalis subsp. lactis (Bb12) and trypsin casein hydrolysate", FOOD CHEMISTRY, ELSEVIER LTD, NL, vol. 123, no. 2, 15 November 2010 (2010-11-15), pages 430 - 435, XP027086085, ISSN: 0308-8146, [retrieved on 20100613]
ANADÓN A ET AL: "Acute and repeated dose (4 weeks) oral toxicity studies of two antihypertensive peptides, RYLGY and AYFYPEL, that correspond to fragments (90-94) and (143-149) from[alpha]s1-casein", FOOD AND CHEMICAL TOXICOLOGY, vol. 48, no. 7, 2010, pages 1836 - 1845, XP085414320, ISSN: 0278-6915, DOI: 10.1016/J.FCT.2010.04.016
ANONYMOUS: "Blood Pressure Health - Ingredients", 10 March 2018 (2018-03-10), pages 1 - 7, XP055667316, Retrieved from the Internet
TOWNSEND R R ET AL: "A randomized, double-blind, placebo-controlled trial of casein protein hydrolysate (C12 peptide) in human essential hypertension", AMERICAN JOURNAL OF HYPERTENSION, NATURE PUBLISHING GROUP, UNITED STATES, vol. 17, no. 11, 1 November 2004 (2004-11-01), pages 1056 - 1058, XP004632273, ISSN: 0895-7061, DOI: 10.1016/J.AMJHYPER.2004.06.018
HIDEAKI K ET AL: "Antihypertensive effect of tryptic hydrolysate of milk casein in spontaneously hypertensive rats", COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. C. COMPARATIVEPHARMACOLOGY, PERGAMON PRESS , OXFORD, GB, vol. 96, no. 2, 1 January 1990 (1990-01-01), pages 367 - 371, XP025890577, ISSN: 0306-4492, [retrieved on 19900101], DOI: 10.1016/0742-8413(90)90023-3
MARIEKE H. SCHOEMAKER ET AL: "A casein hydrolysate based formulation attenuates obesity and associated non-alcoholic fatty liver disease and atherosclerosis in LDLr-/-.Leiden mice", PLOS ONE, vol. 12, no. 7, 5 July 2017 (2017-07-05), pages e0180648, XP055458592, DOI: 10.1371/journal.pone.0180648
TIM T. LAMBERS ET AL: "Clustering analyses in peptidomics revealed that peptide profiles of infant formulae are descriptive", FOOD SCIENCE & NUTRITION, vol. 3, no. 1, 30 December 2014 (2014-12-30), pages 81 - 90, XP055667844, ISSN: 2048-7177, DOI: 10.1002/fsn3.196
WANG BO ET AL: "The absorbates of positively charged peptides from casein show high inhibition ability of LDL oxidationin vitro: Identification of intact absorbed peptides", JOURNAL OF FUNCTIONAL FOODS, ELSEVIER BV, NL, vol. 20, 1 December 2015 (2015-12-01), pages 380 - 393, XP029360092, ISSN: 1756-4646, DOI: 10.1016/J.JFF.2015.11.012
JIAN MING WEI ET AL: "Experimental research Ginkgo suppresses atherosclerosis through downregulating the expression of connexin 43 in rabbits", ARCHIVES OF MEDICAL SCIENCE, vol. 2, 1 January 2013 (2013-01-01), pages 340 - 346, XP055667879, ISSN: 1734-1922, DOI: 10.5114/aoms.2013.34416
ALHAJ O A ET AL: "Hypocholesterolaemic effect of Bifidobacterium animalis subsp. lactis (Bb12) and trypsin casein hydrolysate", FOOD CHEMISTRY, ELSEVIER LTD, NL, vol. 123, no. 2, 15 November 2010 (2010-11-15), pages 430 - 435, XP027086085, ISSN: 0308-8146, [retrieved on 20100613]
ANADÓN A ET AL: "Acute and repeated dose (4 weeks) oral toxicity studies of two antihypertensive peptides, RYLGY and AYFYPEL, that correspond to fragments (90-94) and (143-149) from[alpha]s1-casein", FOOD AND CHEMICAL TOXICOLOGY, vol. 48, no. 7, 2010, pages 1836 - 1845, XP085414320, ISSN: 0278-6915, DOI: 10.1016/J.FCT.2010.04.016
Attorney, Agent or Firm:
CARPINTERO LOPEZ, Mario (ES)
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