CATALYTIC ANTIOXIDANTS AND METHODS OF USE

Title:

CATALYTIC ANTIOXIDANTS AND METHODS OF USE

Document Type and Number:

WIPO Patent Application WO2004047772

Kind Code:

A3

Abstract:

The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some embodiments of the catalytic antioxidant compounds are derived from drugs with anti-inflammatory activity due to inhibition of cyclooxygenase enzymes.

Inventors:

WEISSBACH HERBERT
BROT NATHAN

Application Number:

PCT/US2003/038817

Publication Date:

July 15, 2004

Filing Date:

November 26, 2003

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Assignee:

UNIV FLORIDA ATLANTIC (US)
HOSPITAL FOR SPECIAL SURGERY (US)

International Classes:

C07C317/44; C07C317/50; C07C323/59; C07C323/60; C07D209/26; C07D307/58; C07K5/06; C07K5/065; A61K38/00; (IPC1-7): C07C323/32

Foreign References:

US5401774A

1995-03-28

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