Title:
CATALYTIC ASYMMETRIC AMINOHYDROXYLATION WITH AMINO-SUBSTITUTED HETEROCYCLES
Document Type and Number:
WIPO Patent Application WO2000010977
Kind Code:
A9
Abstract:
Amino-substituted heterocycles are disclosed to be suitable nitrogen sources for the osmium catalyzed asymmetric aminohydroxylation of olefins, achieving suprafacial, vicinal addition of a heterocycle moiety and a hydroxyl group. The enantioselectivities are strongly dependent on the nature of the heterocycles and are comparable to those of standard nitrogen sources. Instead of merely providing a route to protected aminoalcohols, the AA can now also be considered as a means to introduce complex substructures to hydrocarbon backbones.
Inventors:
SHARPLESS K BARRY (US)
GOOSSEN LUKAS J (DE)
LIU HONG (US)
DRESS KLAUS R (US)
GOOSSEN LUKAS J (DE)
LIU HONG (US)
DRESS KLAUS R (US)
Application Number:
PCT/US1999/018998
Publication Date:
December 14, 2000
Filing Date:
August 20, 1999
Export Citation:
Assignee:
SCRIPPS RESEARCH INST (US)
SHARPLESS K BARRY (US)
GOOSSEN LUKAS J (DE)
LIU HONG (US)
DRESS KLAUS R (US)
SHARPLESS K BARRY (US)
GOOSSEN LUKAS J (DE)
LIU HONG (US)
DRESS KLAUS R (US)
International Classes:
C07D213/74; C07D239/42; C07D251/22; C07D253/07; (IPC1-7): C07D213/72; C07D239/02; C07D251/12; C07D253/06; C07D263/30; C07D277/20; C07D487/02
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