Title:
CATIONIC LIPID COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/186041
Kind Code:
A1
Abstract:
Disclosed are a cationic lipid compound, and a preparation method therefor and use thereof. Hydroxyl is introduced into the cationic lipid compound at the head, and meanwhile, the overall structure is similar to a cone with a small head and a large tail. By means of structural improvement, a lipid nanoparticle prepared from the cationic lipid compound has better biocompatibility and higher in-vivo mRNA transfection efficiency, achieving an unexpected technical effect. The disclosed cationic lipid compound has a simple synthesis route which is easy to implement, and has cheap and readily available raw materials, thereby facilitating industrial production. The lipid nanoparticle prepared from the cationic lipid compound has a stable nanostructure, can be stored for a long time at a low temperature, prolongs the shelf life of drugs, and reduces the transportation condition of the drugs.
Inventors:
ZHANG XUEQING (CN)
Application Number:
PCT/CN2023/085225
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
RONGCAI SHANGHAI BIOTECH CO LTD (CN)
UNIV SHANGHAI JIAOTONG (CN)
UNIV SHANGHAI JIAOTONG (CN)
International Classes:
A61K39/00; C07C219/06
Domestic Patent References:
| WO2020061367A1 | 2020-03-26 | |||
| WO2021142280A1 | 2021-07-15 | |||
| WO2022060871A1 | 2022-03-24 |
Foreign References:
| CN114890907A | 2022-08-12 | |||
| CN115710192A | 2023-02-24 | |||
| CN113402405A | 2021-09-17 | |||
| CN108368028A | 2018-08-03 | |||
| CN110520409A | 2019-11-29 |
Attorney, Agent or Firm:
XU & PARTNERS , LLC. (CN)
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