Title:
CATIONIC LIPID COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/241577
Kind Code:
A1
Abstract:
The present application relates to the field of drug carriers, and specifically discloses a cationic lipid compound, and a preparation method therefor and a use thereof. The cationic lipid compound comprises a compound represented by formula I; in the formula I, n is equal to 1, 2, 3 or 4; R1 and R2 are each independently selected from secondary long-chain alkyl esters represented by formula II; in the formula II, n1=2, 4 or 6, n2=5, 7, 9 or 11, and n3=5, 7, 9 or 11. The cationic lipid compound is combined with phospholipids, cholesterol and polyethylene glycol lipids, such that an LNP carrier may be prepared, and then nucleic acid molecules are wrapped to prepare a corresponding drug. The raw materials for the production of the cationic lipid compound in the present application are easy to obtain, the synthesis steps are simple, the constructed LNP carrier has a good drug delivery effect, the corresponding drug can efficiently enter a target cell or activate an immune response of an organism, and thus the cationic lipid compound has practical application value.
Inventors:
WU KANGZENG (CN)
XU FENGWEI (CN)
DAI YONGCHAO (CN)
LIU YU (CN)
XU YUHONG (CN)
XU FENGWEI (CN)
DAI YONGCHAO (CN)
LIU YU (CN)
XU YUHONG (CN)
Application Number:
PCT/CN2023/099945
Publication Date:
December 21, 2023
Filing Date:
June 13, 2023
Export Citation:
Assignee:
HIGHFIELD BIOPHARMACEUTICALS CORP (CN)
International Classes:
C07C229/16; A61K9/127; A61K48/00; C07C227/06
Domestic Patent References:
| WO2021030701A1 | 2021-02-18 |
Foreign References:
| CN101643418A | 2010-02-10 | |||
| CN102625696A | 2012-08-01 | |||
| CN103096875A | 2013-05-08 | |||
| CN104321304A | 2015-01-28 | |||
| CN105085292A | 2015-11-25 | |||
| CN111164068A | 2020-05-15 | |||
| CN113164379A | 2021-07-23 | |||
| US20040077888A1 | 2004-04-22 | |||
| US20210198200A1 | 2021-07-01 |
Attorney, Agent or Firm:
BEIJING WEIZHENG PATENT AGENCY CO., LTD. (CN)
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