CATIONIC OIL-IN-WATER EMULSIONS

Title:

CATIONIC OIL-IN-WATER EMULSIONS

Document Type and Number:

WIPO Patent Application WO/2012/006380

Kind Code:

A3

Abstract:

This invention generally relates to cationic oil-in-water emulsions that can be used to deliver negatively charged molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a cationic lipid. The cationic lipid can interact with the negatively charged molecule thereby anchoring the molecule to the emulsion particles. The cationic emulsions described herein are particularly suitable for delivering nucleic acid molecules (such as an RNA molecule encoding an antigen) to cells and formulating nucleic acid-based vaccines.

More Like This:

JP2020014460	NOVEL IMMUNOTHERAPY FOR SEVERAL TUMORS OF BLOOD, IN PARTICULAR CHRONIC LYMPHATIC LEUKEMIA (CLL)
WO/2005/040338	CONSTRAINED ALKALOID IMMUNOGENS AND ANTIBODIES AND USES THEREOF
WO/2021/162457	ANTICANCER THERAPY USING FAECALIBACTERIUM SP. MICROORGANISM

Inventors:

BRITO LUIS (US)
GEALL ANDREW (US)
O'HAGAN DEREK (US)
SINGH MANMOHAN (US)

Application Number:

PCT/US2011/043108

Publication Date:

July 05, 2012

Filing Date:

July 06, 2011

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NOVARTIS AG (CH)
BRITO LUIS (US)
GEALL ANDREW (US)
O'HAGAN DEREK (US)
SINGH MANMOHAN (US)

International Classes:

A61K39/00; A61K9/107

Domestic Patent References:

WO2000050006A2	2000-08-31
WO2011005799A2	2011-01-13

Foreign References:

EP1723972A1

2006-11-22

Other References:

MALONE R W ET AL: "CATIONIC LIPOSOME-MEDIATED RNA TRANSFECTION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 86, no. 16, 1 August 1989 (1989-08-01), pages 6077 - 6081, XP000604642, ISSN: 0027-8424, DOI: 10.1073/PNAS.86.16.6077

Attorney, Agent or Firm:

LEE, Helen et al. (Inc.IP Services M/S X-100B,PO Box 809, Emeryville CA, US)

Download PDF:

View/Download PDF PDF Help

Previous Patent: METHOD AND APPARATUS FOR CROSS DRM DOMAIN REGISTRATION

Next Patent: CLAMSHELL DOOR HANDLE GRASPER