CCK SECRETION-PROMOTING PEPTIDE TARGETING CALCIUM SENSING RECEPTOR AND METHOD FOR PREPARING SAME AND USE THEREOF - UNIV OF SHANGHAI FOR SCIENCE AND TECHNOLOGY

Title:

CCK SECRETION-PROMOTING PEPTIDE TARGETING CALCIUM SENSING RECEPTOR AND METHOD FOR PREPARING SAME AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/001484

Kind Code:

A1

Abstract:

Provided is a CCK secretion-promoting peptide QGDVVALPA targeting a calcium sensing receptor. The peptide can be artificially synthesized by adopting a chemical solid-phase synthesis method and can also be obtained after enzymolysis, separation, and purification of avenin. The peptide can target an intestinal endocrine cell membrane CaSR to activate a Gq signaling pathway, so that the concentration of intracellular calcium ions is improved to significantly promote secretion of CCK by intestinal endocrine cells. The peptide is safe, non-toxic and side effect-free, resistant to enzymolysis by a gastrointestinal digestive enzyme, and easy to absorb, and thus is suitable for being used as a functional component or a food base material for developing food, health food, and medicines with functions of delaying gastric emptying, promoting satiety, and losing weight.

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Inventors:

GUAN XIAO (CN)
SONG HONGDONG (CN)
HUANG KAI (CN)
FU QIUYUN (CN)

Application Number:

PCT/CN2023/091021

Publication Date:

January 04, 2024

Filing Date:

April 27, 2023

Export Citation:

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Assignee:

UNIV OF SHANGHAI FOR SCIENCE AND TECHNOLOGY (CN)

International Classes:

C07K14/415; A23L33/18; A61K38/16; A61P3/04; C07K1/16; C12N15/29; C12P21/06

Foreign References:

CN115353553A	2022-11-18
CN101709321A	2010-05-19
CN102559821A	2012-07-11
CN104928339A	2015-09-23
CN108715600A	2018-10-30
CN108794590A	2018-11-13
CN110678198A	2020-01-10
US6153592A	2000-11-28

Other References:

张太 (ZHANG, TAI): "稻米储藏过程蛋白质结构、功能性质和体外消化特性变化的研究 (Non-official translation: Studies on the Changes in Protein Structure, Functional Properties and in Vitro Digestive Characteristics During Rice Storage)", 中国优秀硕士学位论文全文数据库工程科技I辑 (ENGINEERING SCIENCE & TECHNOLOGY I, CHINA MASTER’S THESES FULL-TEXT DATABASE), no. 03, 15 March 2022 (2022-03-15)

Attorney, Agent or Firm:

BEIJING SHENGZHOU PATENT AGENCY (GENERAL PARTNERSHIP) (CN)

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