Title:
CD RING SIDE CHAIN-SUBSTITUTED VITAMIN D DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/068322
Kind Code:
A1
Abstract:
Provided is a new vitamin D derivative that is useful for preventing or treating cancer or psoriasis. The vitamin D derivative is a compound represented by general formula (I) (in the formula, X represents a linear or branched alkyl group having 1-8 carbon atoms and optionally substituted with a hydroxyl group, or represents a linear or branched alkenyl group having 1-8 carbon atoms and optionally substituted with a hydroxyl group, and Y represents a linear or branched alkyl group that has 1-12 carbon atoms, that is substituted with at least one halogen atom, and that is optionally substituted with a hydroxyl group).
Inventors:
KITTAKA ATSUSHI (JP)
KAWAGOE FUMIHIRO (JP)
SAKAKI TOSHIYUKI (JP)
YASUDA KAORI (JP)
KAWAGOE FUMIHIRO (JP)
SAKAKI TOSHIYUKI (JP)
YASUDA KAORI (JP)
Application Number:
PCT/JP2022/039059
Publication Date:
April 27, 2023
Filing Date:
October 20, 2022
Export Citation:
Assignee:
UNIV TEIKYO (JP)
International Classes:
C07C401/00; A61K31/593; A61P3/02; A61P17/06; A61P35/00
Domestic Patent References:
| WO2004067504A1 | 2004-08-12 | |||
| WO2004033420A1 | 2004-04-22 |
Foreign References:
| JP2018521010A | 2018-08-02 |
Other References:
IWASAKI, H. HOSOTANI, R. MIYAMOTO, Y. NAKANO, Y. YAMAMOTO, K. YAMADA, S. SHINKI, T. SUDA, T. YAMAGUCHI, K. KONNO, K. TAKAYAMA, H.: "Stereoselective Synthesis and Structural Establishment of (25S)-24,24-Difluoro-1@a,25,26-trihydroxyvitamin D"3, a Major Metabolite of 24,24-Difluoro-1@a,25-dihydroxyvitamin D"3", TETRAHEDRON, vol. 54, no. 49, 3 December 1998 (1998-12-03), AMSTERDAM, NL , pages 14705 - 14724, XP004142596, ISSN: 0040-4020, DOI: 10.1016/S0040-4020(98)00949-1
25 April 2022, 96(4), 181, 1-IV-3, (Vitamins)
25 April 2022, 96(4), 181, 1-IV-4, (Vitamins)
25 April 2022, 96(4), 185, 2-II-4, (Vitamins)
25 April 2022, 96(4), 181, 1-IV-3, (Vitamins)
25 April 2022, 96(4), 181, 1-IV-4, (Vitamins)
25 April 2022, 96(4), 185, 2-II-4, (Vitamins)
Attorney, Agent or Firm:
YAMAGUCHI Kenjiro (JP)
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