Title:
CD31 MIMETIC COATING FOR ENDOVASCULAR STENT
Document Type and Number:
WIPO Patent Application WO/2023/099748
Kind Code:
A3
Abstract:
Inventors have synthesized peptides allowing an engagement of intact CD31 molecules on all the healthy endothelial cells and resting blood platelets and leukocytes that can enter in contact with an implanted device. Those cells can therefore receive the "leave-me-alone" signal delivered by the trans-homophilic engagement of CD31, which is essential to maintain the homeostasis in the circulation and vascularized tissues. Thrombotic or life-threatening occurrence of hemorrhagic or thromboembolic complications have impaired the use of endovascular devices. The devices bearing the mimicking peptides of the present invention are rapidly integrated, because they are perceived by blood platelets and leukocytes as a healthy endothelium, a "self" component. Furthermore, their ability to be rapidly endothelialized with a physiologic endothelial cell phenotype also limits platelet and leukocyte activation at the site of device implantation in the long-term.Accordingly, the present invention relates to peptides mimicking the trans-homophilic CD31-CD31 domain 1 and 2 intercellular interaction.
Inventors:
CALIGIURI GIUSEPPINA (FR)
NICOLETTI ANTONINO (FR)
SKARBEK CHARLES (FR)
BIANCHI ELISABETTA (IT)
INGENITO RAFFAELE (IT)
NICOLETTI ANTONINO (FR)
SKARBEK CHARLES (FR)
BIANCHI ELISABETTA (IT)
INGENITO RAFFAELE (IT)
Application Number:
PCT/EP2022/084241
Publication Date:
July 13, 2023
Filing Date:
December 02, 2022
Export Citation:
Assignee:
INST NAT SANTE RECH MED (FR)
UNIV PARIS CITE (FR)
UNIV PARIS XIII PARIS NORD (FR)
UNIV PARIS CITE (FR)
UNIV PARIS XIII PARIS NORD (FR)
International Classes:
A61L31/00; A61K38/00; A61P9/10; C07K14/705
Domestic Patent References:
| WO2020109833A1 | 2020-06-04 | |||
| WO2010000741A1 | 2010-01-07 | |||
| WO2013190014A1 | 2013-12-27 |
Other References:
DIAZ-RODRIGUEZ SERGIO ET AL: "Coronary stent CD31-mimetic coating favours endothelialization and reduces local inflammation and neointimal development in vivo.", EUROPEAN HEART JOURNAL 07 05 2021, vol. 42, no. 18, 7 May 2021 (2021-05-07), pages 1760 - 1769, XP055945712, ISSN: 1522-9645
QUOCTHANG HOANG ET AL: "Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury", INTENSIVE CARE MEDICINE EXPERIMENTAL, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 15 August 2018 (2018-08-15), pages 1 - 12, XP021259664, DOI: 10.1186/S40635-018-0192-3
WERNER HELD ET AL: "Cis-trans interactions of cell surface receptors: biological roles and structural basis", CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, vol. 68, no. 21, 24 August 2011 (2011-08-24), pages 3469 - 3478, XP019964063, ISSN: 1420-9071, DOI: 10.1007/S00018-011-0798-Z
CORTESE JONATHAN ET AL: "CD31 Mimetic Coating Enhances Flow Diverting Stent Integration into the Arterial Wall Promoting Aneurysm Healing", STROKE, vol. 52, no. 2, 1 February 2021 (2021-02-01), US, pages 677 - 686, XP093032945, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.120.030624
QUOCTHANG HOANG ET AL: "Peptide binding to cleaved CD31 dampens ischemia/reperfusion-induced intestinal injury", INTENSIVE CARE MEDICINE EXPERIMENTAL, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 15 August 2018 (2018-08-15), pages 1 - 12, XP021259664, DOI: 10.1186/S40635-018-0192-3
WERNER HELD ET AL: "Cis-trans interactions of cell surface receptors: biological roles and structural basis", CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, vol. 68, no. 21, 24 August 2011 (2011-08-24), pages 3469 - 3478, XP019964063, ISSN: 1420-9071, DOI: 10.1007/S00018-011-0798-Z
CORTESE JONATHAN ET AL: "CD31 Mimetic Coating Enhances Flow Diverting Stent Integration into the Arterial Wall Promoting Aneurysm Healing", STROKE, vol. 52, no. 2, 1 February 2021 (2021-02-01), US, pages 677 - 686, XP093032945, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.120.030624
Attorney, Agent or Firm:
INSERM TRANSFERT (FR)
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