Title:
CD4 BINDING AGENTS AND INHIBITORS OF COLLAGENASE AND PROTEIN KINASE C
Document Type and Number:
WIPO Patent Application WO1993018173
Kind Code:
A3
Abstract:
A compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C27H16O12, a molecular weight of 532 and defined spectral characteristics; a compound which is obtainable from Penicillium glabrum X8063 (CMI 336456) and which has a molecular formula of C14 H10O6, a molecular weight of 274 and defined spectral characteristics; anhydrofulvic acid; and citromycetin; and pharmaceutically and veterinarily acceptable salts, esters and ethers thereof; are useful as CD4 binding agents, inhibitors of collagenase and in the case of the compound of molecular formula C27H16O12 and the compound having the molecular formula C14H10O6 inhibitors of protein kinase C.
Inventors:
HYLANDS PETER JOHN (GB)
WRIGLEY STEPHEN KEITH (GB)
CHANDLER GLENDA LOUISE (GB)
COLLINS MARK ANTHONY DAVID (GB)
FOX FRANCES (GB)
MOORE MICHAEL (GB)
WRIGLEY STEPHEN KEITH (GB)
CHANDLER GLENDA LOUISE (GB)
COLLINS MARK ANTHONY DAVID (GB)
FOX FRANCES (GB)
MOORE MICHAEL (GB)
Application Number:
PCT/GB1993/000511
Publication Date:
October 28, 1993
Filing Date:
March 11, 1993
Export Citation:
Assignee:
XENOVA LTD (GB)
International Classes:
A61K31/35; C07D493/04; C12P1/02; C12P17/16; C12P17/18; (IPC1-7): C12P17/16; A61K31/35; C07D493/04; C12P1/02; C12P17/18
Domestic Patent References:
| WO1992016517A1 | 1992-10-01 |
Foreign References:
| EP0319333A2 | 1989-06-07 |
Other References:
J. CHEM. SOC. PERKIN TRANSACTION I, 1987 no. 2, 1987, ROYAL SOCIETY OF CHEM., LONDON UK; pages 395 - 398 M. YAMAUCHI ET AL. 'Studies on the syntheses of heterocyclic compounds containing benzopyrone. Part6. Biomimetic total syntheses of citromycetin'
T. KORZYBSKI ET AL. IN: ANTIBIOTICS vol. II, 1967, PERGAMON PRESS,OXFORD, UK; pages 1254 - 1255 'Frequentic acid, syn. Citromycetin' the whole document
J. CHEM. SOC. PERKIN TRANSACTION I 1988 no. 4, April 1988, ROYAL SOCIETY OF CHEM., LONDON, UK; pages 763 - 768 A.K. DEMETRIADOU ET AL. 'Isolation and structure elucidation of polivione, a polyketide co-metabolite of citromycetin in Penecillium frequentans' cited in the application the whole document
T. KORZYBSKI ET AL. IN: ANTIBIOTICS vol. II, 1967, PERGAMON PRESS,OXFORD, UK; pages 1254 - 1255 'Frequentic acid, syn. Citromycetin' the whole document
J. CHEM. SOC. PERKIN TRANSACTION I 1988 no. 4, April 1988, ROYAL SOCIETY OF CHEM., LONDON, UK; pages 763 - 768 A.K. DEMETRIADOU ET AL. 'Isolation and structure elucidation of polivione, a polyketide co-metabolite of citromycetin in Penecillium frequentans' cited in the application the whole document
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