Title:
CD7-CAR-T CELL AND PREPARATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/098882
Kind Code:
A1
Abstract:
A CD7-CAR-T cell and preparation and application thereof. Specifically, the present invention provides a chimeric antigen receptor (CAR), and an antigen binding domain of the CAR comprises one or more CD7 nanobodies. The present invention further provides a CAR-T cell containing the CAR, and an endogenous CD7 expression of the CAR-T cell is blocked. The CAR-T cell can be used for treatment of T cell tumors.
Inventors:
YANG LIN (CN)
YOU FENGTAO (CN)
CHEN DAN (CN)
YOU FENGTAO (CN)
CHEN DAN (CN)
Application Number:
PCT/CN2020/130945
Publication Date:
May 27, 2021
Filing Date:
November 23, 2020
Export Citation:
Assignee:
PERSONGEN BIOTHERAPEUTICS SUZHOU CO LTD (CN)
International Classes:
C07K16/18; A61K38/05; A61P37/02; C12N5/10; C12N15/62
Domestic Patent References:
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| WO2001096584A2 | 2001-12-20 | |||
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Foreign References:
| CN109652379A | 2019-04-19 | |||
| CN108884164A | 2018-11-23 | |||
| CN109912683A | 2019-06-21 | |||
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Other References:
SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY
UI-TEI ET AL., FEBS LETTERS, vol. 479, 2000, pages 79 - 82
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
SAMBROOK ET AL.: "Molecule Clone: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 4083067A4
UI-TEI ET AL., FEBS LETTERS, vol. 479, 2000, pages 79 - 82
ROSENBERG ET AL., NEW ENG. J. OF MED., vol. 319, 1988, pages 1676
SAMBROOK ET AL.: "Molecule Clone: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 4083067A4
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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