Title:
CD73 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2020/211668
Kind Code:
A1
Abstract:
Disclosed are compounds that are inhibitors of CD73 and are useful in treating CD73-associated diseases or conditions, and compositions containing the compounds.
Inventors:
CHEN DIANJUN (CN)
BAILEY SIMON (US)
FENG JIANXIA (CN)
KAYSER FRANK (US)
LIU CHONG (CN)
YUAN HONGBIN (CN)
BAILEY SIMON (US)
FENG JIANXIA (CN)
KAYSER FRANK (US)
LIU CHONG (CN)
YUAN HONGBIN (CN)
Application Number:
PCT/CN2020/083200
Publication Date:
October 22, 2020
Filing Date:
April 03, 2020
Export Citation:
Assignee:
BIOARDIS LLC (US)
CHEN DIANJUN (CN)
CHEN DIANJUN (CN)
International Classes:
A61K31/517; C07D239/94; A61K31/519; A61P35/00; C07D239/78; C07D239/88; C07D307/20; C07D471/04; C07F9/20; C07F9/32; C07H7/06; C07H13/00
Domestic Patent References:
| WO2018208727A1 | 2018-11-15 | |||
| WO2015164573A1 | 2015-10-29 | |||
| WO2017161349A1 | 2017-09-21 | |||
| WO2018208980A1 | 2018-11-15 | |||
| WO2018035410A1 | 2018-02-22 | |||
| WO2018049145A1 | 2018-03-15 | |||
| WO2017098421A1 | 2017-06-15 |
Other References:
RAO，KAMBHAMPATI V. B. ET AL.: "Synthesis of the pyrido[4, 3-d]pyrimidine congeners of inosine and of adenosine - a new class of 6:6 bicyclic C-ribofuranosides", NUCLEOSIDES & NUCLEOTIDES, vol. 11, no. 1, 31 December 1992 (1992-12-31), pages 61 - 83, ISSN: 0732-8311, DOI: 20200604164448A
HERNANDEZ， ARMANDO R. ET AL.: "The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides", ORGANIC LETTERS, vol. 13, no. 4, 7 January 2011 (2011-01-07), pages 676 - 679, XP055743691, ISSN: 1523-7052, DOI: 20200604165009A
DUMONTET， CHARLES ET AL.: "CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, 17 August 2018 (2018-08-17), pages 1051 - 1055, XP085491764, ISSN: 0223--523, DOI: 20200604170112A
HERNANDEZ， ARMANDO R. ET AL.: "The Components of xRNA: Synthesis and Fluorescence of a Full Genetic Set of Size-Expanded Ribonucleosides", ORGANIC LETTERS, vol. 13, no. 4, 7 January 2011 (2011-01-07), pages 676 - 679, XP055743691, ISSN: 1523-7052, DOI: 20200604165009A
DUMONTET， CHARLES ET AL.: "CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 157, 17 August 2018 (2018-08-17), pages 1051 - 1055, XP085491764, ISSN: 0223--523, DOI: 20200604170112A
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
Download PDF: