Title:
CELL ACTIVATOR, CELL DEATH INHIBITOR AND CELL DEATH PROMOTER
Document Type and Number:
WIPO Patent Application WO/2006/073181
Kind Code:
A1
Abstract:
A cell activator or a cell death inhibitor comprising Wnt5a and/or Wnt10a as the active ingredients. A cell activator, a cell death inhibitor or a cell death promoter which indirectly acts on a target cell by controlling the secretion of Wnt5a and/or Wnt10a from the cell is also included therein. In the above-described cell activator or cell death inhibitor, orange, etc. may be used as a substance promoting the secretion of Wnt5a from a cell while echinacea may be used as a substance inhibiting the same. It is furthermore intended to provide a hair growing agent, a hair nourishment and a hair growth stimulant comprising the cell activator or the cell death inhibitor as described above as an active ingredient and a hair removal agent comprising the cell death promoter as described above as the active ingredient.
Inventors:
KAWASAKI AYA
YAMASHITA YUKI
TORII KOSUKE
TERASHITA KENZO
AISO SADAKAZU
MATSUOKA MASAAKI
NISHIMOTO IKUO
YAMASHITA YUKI
TORII KOSUKE
TERASHITA KENZO
AISO SADAKAZU
MATSUOKA MASAAKI
NISHIMOTO IKUO
Application Number:
PCT/JP2006/300090
Publication Date:
July 13, 2006
Filing Date:
January 06, 2006
Export Citation:
Assignee:
NOEVIR KK (JP)
KAWASAKI AYA
YAMASHITA YUKI
TORII KOSUKE
TERASHITA KENZO
AISO SADAKAZU
MATSUOKA MASAAKI
NISHIMOTO IKUO
KAWASAKI AYA
YAMASHITA YUKI
TORII KOSUKE
TERASHITA KENZO
AISO SADAKAZU
MATSUOKA MASAAKI
NISHIMOTO IKUO
International Classes:
A61K38/00; A61K8/97; A61K31/198; A61K36/18; A61K36/28; A61K36/53; A61K36/75; A61K45/00; A61P17/14; A61P43/00; A61Q7/00
Domestic Patent References:
| WO2002056849A1 | 2002-07-25 | |||
| WO2003086334A1 | 2003-10-23 |
Foreign References:
| JP2004500407A | 2004-01-08 | |||
| JPH11228355A | 1999-08-24 | |||
| JPH09221413A | 1997-08-26 | |||
| JP2003522779A | 2003-07-29 | |||
| JP2002515401A | 2002-05-28 | |||
| JP2004035531A | 2004-02-05 | |||
| JPH09202798A | 1997-08-05 | |||
| JPH04342517A | 1992-11-30 | |||
| JPH1121245A | 1999-01-26 | |||
| JPH10194936A | 1998-07-28 | |||
| JP2000169333A | 2000-06-20 | |||
| JP2005041871A | 2005-02-17 |
Other References:
LISOVSKY M. ET AL.: "FRIZZLED RECEPTORS ACTIVATE A NOVEL JNK-DEPENDENT PATHWAY THAT MAY LEAD TO APOPTOSIS", CURR.BIOL., vol. 12, no. 1, 2002, pages 53 - 58
ERDDY S. ET AL.: "CHARACTERIZATION OF WNT GENE EXPRESSION IN DEVELOPING AND POSTNATAL HAIR FOLLICLES AND IDENTIFICATION OF WNT5A AS A TARGET OF SONIC HEDGEHOG IN HAIR FOLLICLE PORPHOGENESIS", MECH. DEV., vol. 107, no. 1-2, 2001, pages 69 - 82
ANDL T. ET AL.: "DISRUPTION OF WNT-FRIZZLED INTERACTIONS INHIBITS HAIR GROWTH", JOURNAL OR INVESTIGATIVE DERMATOLOGY, vol. 117, no. 2, 2001, pages 217 - 426
GAT U. ET AL.: "DE NOVO HAIR FOLLICLE MORPHOGENESIS AND HAIR TUMORS IN MICE EXPRESSING A TRUNCATED BETA-CATENIN IN SKIN", CELL, vol. 95, no. 5, 1998, pages 605 - 614, XP000891225, DOI: doi:10.1016/S0092-8674(00)81631-1
ERDDY S. ET AL.: "CHARACTERIZATION OF WNT GENE EXPRESSION IN DEVELOPING AND POSTNATAL HAIR FOLLICLES AND IDENTIFICATION OF WNT5A AS A TARGET OF SONIC HEDGEHOG IN HAIR FOLLICLE PORPHOGENESIS", MECH. DEV., vol. 107, no. 1-2, 2001, pages 69 - 82
ANDL T. ET AL.: "DISRUPTION OF WNT-FRIZZLED INTERACTIONS INHIBITS HAIR GROWTH", JOURNAL OR INVESTIGATIVE DERMATOLOGY, vol. 117, no. 2, 2001, pages 217 - 426
GAT U. ET AL.: "DE NOVO HAIR FOLLICLE MORPHOGENESIS AND HAIR TUMORS IN MICE EXPRESSING A TRUNCATED BETA-CATENIN IN SKIN", CELL, vol. 95, no. 5, 1998, pages 605 - 614, XP000891225, DOI: doi:10.1016/S0092-8674(00)81631-1
Attorney, Agent or Firm:
Miyoshi, Hidekazu (2-8 Toranomon 1-chome, Minato-k, Tokyo 01, JP)
Download PDF: