CELL AGGREGATE INCLUDING RETINAL TISSUE AND PRODUCTION METHOD THEREFOR

WIPO Patent Application WO/2019/050015

A1

This spherical cell aggregate according to one embodiment of the present invention comprises a core section including a neural retina, and a cover section continuously or non-continuously covering at least a portion of the surface of the core section, and is characterized in that: (1) in the neural retina, a neural retina layer including at least a visual cell layer is formed, the visual cell layer includes at least one type of cells selected from the group consisting of visual cells, visual cell precursor cells, and retina precursor cells, and cells included in the visual cell layer are continuously present in a direction tangential to the surface of the core section; (2) the cover section includes retinal pigment epithelial cells that are in contact with each other; (3) the cell aggregate does not include the crystalline lens, the vitreous body, the cornea, or blood vessels; and (4) the retinal pigment epithelial cells and the neural retina layer do not together form a continuous epithelial structure.

TAKAHASHI MASAYO (JP)
MANDAI MICHIKO (JP)
YAMASAKI SUGURU (JP)

PCT/JP2018/033299

March 14, 2019

September 07, 2018

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RIKEN (JP)
SUMITOMO DAINIPPON PHARMA CO LTD (JP)

C12N5/079; A61K35/30; A61L27/38; A61L27/40; A61P27/02; C12N5/0735; C12Q1/06

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See also references of EP 3680326A4

HASEGAWA Yoshiki et al. (JP)

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