Title:
CELL CAPABLE OF ACTIVATING IMMUNE SYSTEM, AND PHARMACEUTICAL COMPOSITION CONTAINING SAID CELL
Document Type and Number:
WIPO Patent Application WO/2020/251014
Kind Code:
A1
Abstract:
The present invention provides: a cell capable of activating an immune system; and a pharmaceutical composition containing the cell. According to the present invention, a mammalian cell is provided, which has at least one protein selected from early gene E6 protein and E7 protein of a human papillomavirus and CD1d protein and which is pulsed with a CD1d ligand. According to the present invention, a fusion protein comprising E7 protein, E6 protein and E7 protein in this order, a nucleic acid encoding the protein, and a gene expression vector for the nucleic acid are also provided.
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Inventors:
FUJII SHINICHIRO (JP)
SHIMIZU KANAKO (JP)
SHIMIZU KANAKO (JP)
Application Number:
PCT/JP2020/023197
Publication Date:
December 17, 2020
Filing Date:
June 12, 2020
Export Citation:
Assignee:
RIKEN (JP)
International Classes:
A61K39/12; A61K31/7088; A61K35/12; A61K38/16; A61P31/20; A61P35/00; C07K14/025; C07K19/00; C12N5/10; C12N15/37; C12N15/62; C12N15/63
Domestic Patent References:
| WO2007097370A1 | 2007-08-30 | |||
| WO2010061930A1 | 2010-06-03 | |||
| WO2013018778A1 | 2013-02-07 | |||
| WO2007097370A1 | 2007-08-30 | |||
| WO2010061930A1 | 2010-06-03 | |||
| WO2013018778A1 | 2013-02-07 |
Foreign References:
| JP2018518172A | 2018-07-12 | |||
| JP2019514988A | 2019-06-06 | |||
| JP2017507918A | 2017-03-23 | |||
| JP2009534027A | 2009-09-24 |
Other References:
SHIMIZU K. ET AL.: "Tumor Cells Loaded with a-Galactosylceramide Induce Innate NKT and NK Cell -Dependent Resistance to Tumor Implantation in Mice", J. IMMUNOL., vol. 178, 2007, pages 2853 - 2861, XP008149821, DOI: 10.4049/jimmunol.178.5.2853
SHIMIZU K. ET AL., J. IMMUNOL., vol. 178, 2007, pages 2853 - 2861
"GenBank", Database accession no. NP -041325.1
JOURNAL OF MOLECULAR BIOLOGY, vol. 48, 1970, pages 443 - 453
J IMMUNOL., vol. 178, 2007, pages 2853 - 2861
See also references of EP 3984552A4
SHIMIZU K. ET AL., J. IMMUNOL., vol. 178, 2007, pages 2853 - 2861
"GenBank", Database accession no. NP -041325.1
JOURNAL OF MOLECULAR BIOLOGY, vol. 48, 1970, pages 443 - 453
J IMMUNOL., vol. 178, 2007, pages 2853 - 2861
See also references of EP 3984552A4
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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